Hepatitis B virus infection: Current status

Slides:

Advertisements

Similar presentations

Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis Jeffrey S. Berger, MD, MS, David L. Brown, MD, Richard C. Becker, MD The.

Advertisements

Kai Rou Tey, MD, Kristen Barrett, MD, Richa Jain, MD, Thomas D

Bleeding Toes in Diabetic Neuropathy

Pierre Loulergue, MD, MSc, Agnès Guerre, MD

Chronic viral hepatitis type B with “ground glass” cells

The Autopsy of Chicken Nuggets Reads “Chicken Little”

Progression of liver pathology in patients undergoing the Fontan procedure: Chronic passive congestion, cardiac cirrhosis, hepatic adenoma, and hepatocellular.

Frank A. Anania, MD The American Journal of Medicine

Kai Rou Tey, MD, Kristen Barrett, MD, Richa Jain, MD, Thomas D

An Unusual Cause of Leg Ulcerations

Restoring Balance: Paraneoplastic Cerebellar Degeneration

How Well Are Pulses Measured

Bleeding Toes in Diabetic Neuropathy

Pierre Loulergue, MD, MSc, Agnès Guerre, MD

Intravascular Large B Cell Lymphoma Presenting as Transient Erythema Nodosum-Like Lesions and Fever David J. Tsoulis, MD, Danny Ghazarian, MD, Eugenia.

Was It the Zebu? The American Journal of Medicine

Chief Complaint: “People Were Staring”

Bilateral Adrenal Adenomas and Persistent Leukocytosis: A Unique Case of Cushing’s Syndrome Nilay Desai, MD, Anoop Kapoor, MD, Binod K. Singh, MD, Jingxuan.

An Uncommon Cause of Obstructive Jaundice: An Infrequent Neoplasm

Stephanos J. Hadziyannis Journal of Hepatology

Negative Biopsies, Deadly Disease: Metastatic Angiosarcoma

Introduction The American Journal of Medicine

Liver Failure Secondary to Amyloid Light-Chain Amyloidosis

Wegener's Granulomatosis in a Patient with Fever of Unknown Origin

Chronic Diarrhea in a Traveler: Cyclosporiasis

Ashok K. Malani, MD, MS, Brian Olofsson, MD, David Debono, MD

Gynecomastia: Look Beyond the Obvious

Juice Plus or Toxicity Plus

Recurrent Pancreatitis, Rash, and Diarrhea: Crohn's Disease

The Reply The American Journal of Medicine

Alexey Surov, MD, Michael Hainz, MD, Malte Kornhuber, MD

Alex Y. Hui, MD, Henry L. Y. Chan, MD, Choong-Tsek Liew, MD, Paul K. S

Occam's Razor and the Diagnosis of Mantle Cell Lymphoma

Scrotal Swelling and Sarcoidosis

Treatment of hepatitis C

Long-Term Outcome after Hepatitis B Surface Antigen Seroclearance in Patients with Chronic Hepatitis B Yasuji Arase, MD, Kenji Ikeda, MD, Fumitaka Suzuki,

Diabetic Muscle Infarction: Case Report of a Rare Complication

The natural history of post-traumatic hypopituitarism: Implications for assessment and treatment Amar Agha, MD, Jack Phillips, MD, Patrick O’Kelly, MSc,

Hyperviscosity syndrome in an HIV-1—positive patient

A Blast from the Past The American Journal of Medicine

Carlos Aguilar, MD, Valentin del Villar, MD

Rare and Deadly The American Journal of Medicine

Lump in Scrotum and Abnormal Chest X-Ray: What Is the Link?

Treatment of fibrosing cholestatic hepatitis with lamivudine

Hepatitis C virus infection manifesting as tubulointerstitial nephritis, cardiomyopathy, and hepatitis Hitomi Watanabe, MD, Takahiko Ono, MD, PhD, Eri.

A Diagnostic Dilemma in a Patient with Polyarthritis

Gastrointestinal Bleeding: One Complaint, Two Culprits

The Autopsy of Chicken Nuggets Reads “Chicken Little”

Nicholas D Weber, Daniel Stone, Keith R Jerome Molecular Therapy

Unusual Cause of Stridor in an 80-Year-old Man

Volume 56, Issue 6, Pages (June 2012)

Acute Necrotizing Herpetic Pleuritis in a Patient with Systemic Sclerosis and Immunosuppression: Report of a Novel Pulmonary Herpes Infection Despina.

Pulmonary Langerhans' Cell Histiocytosis

The Heart of the Matter The American Journal of Medicine

Systemic Immunoglobulin G4–Related Disease in an Asymptomatic Patient

Kyle W. Mahoney, MD, Jules B. Lipoff, MD, Bennett W. Clark, MD

Sharan Prakash Sharma, MD, Karleung Siu, MD

Eagle's Syndrome The American Journal of Medicine

Ajay Major, MD, MBA, Mel Anderson, MD The American Journal of Medicine

Shikhar Agarwal, MD, MPH The American Journal of Medicine

Cryoglobulinemic Glomerulonephritis in a Patient with Polymyositis

Beware of Underlying Malignancy: Acquired Ichthyosis

Pheochromocytoma Presenting as Fever of Unknown Origin

Waxing and Waning Lymphadenopathy

Renal Failure due to Excessive Intake of Almonds in the Absence of Oxalobacter formigenes Yngvar Lunde Haaskjold, MD, Aslaug Drotningsvik, MSc, Sabine.

Falls in Older Adults: Risk Assessment, Management and Prevention

Emily G. McDonald, MD, MSc, Ramy R. Saleh, MD, Todd C. Lee, MD, MPH

Bijin Thajudeen, MD, Mario F. Rubin, MD

Double Trouble: The Diagnostic Dilemma of Diffuse Alveolar Hemorrhage

David Tian, MD, Ram Jhingan Mohan, MD, Gary Stallings, MD

Presentation transcript:

Hepatitis B virus infection: Current status Ponsiano Ocama, MD, Christopher K. Opio, MD, William M. Lee, MD The American Journal of Medicine Volume 118, Issue 12, Pages 1413.e15-1413.e22 (December 2005) DOI: 10.1016/j.amjmed.2005.06.021 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Overwhelming hepatitis B infection with immunosuppression. Photomicrographs providing evidence that immunosuppression leads to overwhelming infection. A–D: Liver biopsy from a patient who developed severe liver failure after chemotherapy for non-Hodgkin lymphoma, which was ultimately fatal. A: Extensive hepatocyte injury and inflammation involving the portal tract and hepatic lobule. Prominent ground glass cytoplasmic inclusions representing excess HBsAg are present (100× hematoxylin-eosin). B: Severe architectural disruption with intercellular fibrosis and hepatocyte necrosis (fibrosing cholestatic hepatitis) (100× Masson trichrome stain). C: Immunohistochemical stain for HBsAg confirming the overwhelming burden of HBsAg giving diffuse cytoplasmic reactivity in virtually all cells (alkaline phosphatase stain 100×). D: Overwhelming infection is also evident with HBcAg-positive staining in virtually every nucleus and in cytoplasm as well (alkaline phosphatase stain 200×). E, F: In contrast, the same immunohistochemical stains observed above applied to the liver biopsy of a patient with chronic hepatitis B. E: Only a single cell demonstrates immunoreactivity to HBsAg (alkaline phosphatase stain 400×). F: Scattered nuclei are reactive to staining for HBcAg (alkaline phosphatase stain 200×). The American Journal of Medicine 2005 118, 1413.e15-1413.e22DOI: (10.1016/j.amjmed.2005.06.021) Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 2 An algorithm for the management of chronic hepatitis B.19-22 HBV = hepatitis B virus; HBcAg = hepatitis B core antigen; HBsAg = hepatitis B surface antigen; ER = endoplasmic reticulum; cccDNA = covalently closed circular DNA. The American Journal of Medicine 2005 118, 1413.e15-1413.e22DOI: (10.1016/j.amjmed.2005.06.021) Copyright © 2005 Elsevier Inc. Terms and Conditions