A double-blind, placebo-controlled, phase-II clinical trial to evaluate oral simvastatin as a treatment for vitiligo Stefan G. Vanderweil, MD, Shinya.

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Presentation transcript:

A double-blind, placebo-controlled, phase-II clinical trial to evaluate oral simvastatin as a treatment for vitiligo Stefan G. Vanderweil, MD, Shinya Amano, MD, PhD, Wei-Che Ko, MS, Jillian M. Richmond, PhD, Michelle Kelley, MSN, RN, Maryanne Makredes Senna, MD, Andrea Pearson, MD, Sandhya Chowdary, MD, Celia Hartigan, RN, MPH, Bruce Barton, PhD, John E. Harris, MD, PhD Journal of the American Academy of Dermatology Volume 76, Issue 1, Pages 150-151.e3 (January 2017) DOI: 10.1016/j.jaad.2016.06.015 Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Relative change in Vitiligo Area Scoring Index (VASI) score between visits 1 and 4 in placebo (A) and simvastatin (B) groups. Thick purple line represents the mean change of each group. Visit 1, 0 months; Visit 2, 1 month; Visit 3, 3 months; Visit 4, 6 months. Journal of the American Academy of Dermatology 2017 76, 150-151.e3DOI: (10.1016/j.jaad.2016.06.015) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Supplemental Fig 1 Vitiligo Area Scoring Index (VASI) score formula. Journal of the American Academy of Dermatology 2017 76, 150-151.e3DOI: (10.1016/j.jaad.2016.06.015) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Supplemental Fig 2 Comparison of serum CXCL10 levels between treatment and placebo groups. Participant 8 (simvastatin [simv] group) was not included because he withdrew before a second CXCL10 level was obtained. Other withdrawn participants were included, using the CXCL10 from their final visits. NS, Not significant. Journal of the American Academy of Dermatology 2017 76, 150-151.e3DOI: (10.1016/j.jaad.2016.06.015) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions