fackrel@Uwindsor.ca Corona.ppt Corona Viruses fackrel@Uwindsor.ca Corona.ppt
Corona Viruses Structure Classification Multiplication Clinical manifestations Epidemiology Diagnosis Control Baron’s Web Site
Structure Spherical or pleomorphic 80-100 nm Enveloped club shaped glycoprotein spikes ss RNA sense strand
Classification OC43 like 229E like Crown of envelope glycoproteins 2 serotypes OC43 like 229E like
Multiplication Virus enters nasal epithelium Uncoats ssRNA transcribed >>> translated mRNA nested set common 3’ ends only unique portion of 5’ translated
Clinical Manifestations Common Cold mild, acute upper respiratory tract infections Diarrhea in children RARE!
Corona Virus Pathogenesis coryza Nasal Secretions Nasopharynx Time (days) Virus DISEASE Interferon antibody
Epidemiology local epidemics Peak incidence in Winter last few weeks- months
Diagnosis Clinically undistinguished from other colds Laboratory increase in antibody titre over time virus difficult to isolate
Control Treat symptoms Improve hygiene No vaccines No specific antivirals
DONE!!!