Volume 73, Issue 4, Pages 502-511 (April 2018) Prostate Cancer Death After Radiotherapy or Radical Prostatectomy: A Nationwide Population-based Observational Study  David Robinson, Hans Garmo, Ingela Franck Lissbrant, Anders Widmark, Andreas Pettersson, Adalsteinn Gunnlaugsson, Jan Adolfsson, Ola Bratt, Per Nilsson, Pär Stattin  European Urology  Volume 73, Issue 4, Pages 502-511 (April 2018) DOI: 10.1016/j.eururo.2017.11.039 Copyright © 2017 European Association of Urology Terms and Conditions

Fig. 1 Flow chart of selection of study participants from Prostate Cancer data Base Sweden (PCBaSe) 3.0. Pca=prostate cancer; NPCR=National Prostate Cancer Register of Sweden; RP=radical prostatectomy; RT=radiotherapy. a Due to emigration (n=1), death from myocardial infarction at date of surgery (n=1), and date mismatch (n=11). b Later than 2 yr from the date of diagnosis. European Urology 2018 73, 502-511DOI: (10.1016/j.eururo.2017.11.039) Copyright © 2017 European Association of Urology Terms and Conditions

Fig. 2 Hazard ratios for prostate cancer (Pca) death shown for Cancer of the Prostate Risk Assessment (CAPRA) scores, with 95% confidence intervals. CAPRA is a scoring system from 0 to 10 based on age, PSA, Gleason score, clinical stage, and percent of biopsy cores involved with cancer. A high CAPRA score is associated with a poor prognosis [14]. Left truncation of data on January 1, 2011. PSA=prostate-specific antigen; RP=radical prostatectomy; RT=radiotherapy. a An assumption was made that the absolute 10-yr risk of Pca death for RT and RP is directly corresponding to the relative risk estimates. Then by considering the proportion of RT and the absolute 10-yr risk of Pca death for RT and RP combined in each CAPRA score category, an absolute 10-yr risk difference was calculated combining this with the relative risks. European Urology 2018 73, 502-511DOI: (10.1016/j.eururo.2017.11.039) Copyright © 2017 European Association of Urology Terms and Conditions

Fig. 3 Proportion prostate cancer (Pca) death among men treated with radiotherapy (RT) or radical prostatectomy (RP), divided into three time periods of treatment (solid dark green, green and light green lines). Proportion of Pca death during the full study period (dotted dark brown line) and with truncation on more recent dates (dotted light brown lines). European Urology 2018 73, 502-511DOI: (10.1016/j.eururo.2017.11.039) Copyright © 2017 European Association of Urology Terms and Conditions