Sterol-izing Innate Immunity

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Sterol-izing Innate Immunity Courtney Wilkins, Michael Gale Immunity Volume 38, Issue 1, Pages 3-5 (January 2013) DOI: 10.1016/j.immuni.2013.01.002 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Interferon Induction of Ch25h and Antiviral Actions of 25HC Type I (left) and Type II IFN (right) binding to their cognate cell surface receptor chains induces signaling of JAK-STAT pathway components to drive gene expression from IFN-stimulated-response-elements (ISRE) or gamma-activating-sequence elements within the promoter of the Ch25h gene to induce Ch25h expression. Ch25h catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25HC) through 02 and NAPDH cofactors to alter cell membrane permissiveness for fusion of enveloped viruses and also restricts viral replication. Immunity 2013 38, 3-5DOI: (10.1016/j.immuni.2013.01.002) Copyright © 2013 Elsevier Inc. Terms and Conditions