Quantitative Assessment of the Safety Benefits Associated with Increasing Clinical Peanut Thresholds Through Immunotherapy Joseph L. Baumert, PhD, Steve.

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Presentation transcript:

Quantitative Assessment of the Safety Benefits Associated with Increasing Clinical Peanut Thresholds Through Immunotherapy Joseph L. Baumert, PhD, Steve L. Taylor, PhD, Stef J. Koppelman, PhD The Journal of Allergy and Clinical Immunology: In Practice Volume 6, Issue 2, Pages 457-465.e4 (March 2018) DOI: 10.1016/j.jaip.2017.05.006 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Overall approach of quantitative risk assessment. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 457-465.e4DOI: (10.1016/j.jaip.2017.05.006) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Decrease in risk of reaction on consumption of various food products as a function of a change in threshold. NR, No predicted reaction. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 457-465.e4DOI: (10.1016/j.jaip.2017.05.006) Copyright © 2017 The Authors Terms and Conditions

Figure 3 Fold reduction in risk for peanut-allergic individuals on increasing the threshold through immunotherapy. A, Risk reduction when a threshold of 300 mg peanut protein is reached after immunotherapy. B, Risk reduction when a threshold of 1000 mg peanut protein is reached after immunotherapy. Food product categories indicated by gray bars: snack chips mixes; black bars: cookies; dotted bars: doughnuts/snack cakes; dashed bars: ice cream. Note: Panel B for reaching a threshold of 1000 mg is relevant only for ice cream because for the other food product categories no reactions are predicted for individuals who have a threshold of 1000 mg due to the lower consumption quantities involved. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 457-465.e4DOI: (10.1016/j.jaip.2017.05.006) Copyright © 2017 The Authors Terms and Conditions