Fig. 5. Circulating PPi concentration does not correlate with severity of calcification phenotype in mice. Circulating PPi concentration does not correlate with severity of calcification phenotype in mice. (A) Micro-CT scans of the muzzle to evaluate the extent of vibrissae fibrous capsule calcification were obtained at 1 year of age. (B) Quantification of ectopic calcification from micro-CT images. (C) Quantification of plasma PPi concentration. (B and C) A one-way ANOVA with Tukey’s honest significance difference post hoc analysis was performed. One-way ANOVA: (B) P = 1.09 × 10−5; (C) P = 0.0087. P values of post hoc comparisons are indicated in the figure. Shira G. Ziegler et al., Sci Transl Med 2017;9:eaal1669 Published by AAAS