Aditya J. Ullal, BA, Ramy S. Abdelfattah, MD, Euan A

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Hypertrophic Cardiomyopathy as a Cause of Sudden Cardiac Death in the Young: A Meta-Analysis Aditya J. Ullal, BA, Ramy S. Abdelfattah, MD, Euan A. Ashley, MRCP, DPhil, Victor F. Froelicher, MD The American Journal of Medicine Volume 129, Issue 5, Pages 486-496.e2 (May 2016) DOI: 10.1016/j.amjmed.2015.12.027 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Hypertrophic cardiomyopathy as a cause of sudden cardiac death in subjects aged ≤35 years. Forest plots display point estimates from individual studies, along with summary estimates and confidence intervals for the pooled proportion of sudden cardiac deaths caused by hypertrophic cardiomyopathy. The data column headed by “Total HCM” represents the total number of patients with sudden cardiac death due to hypertrophic cardiomyopathy in each study. The column headed by “Total SCDs” indicates the total number of sudden cardiac deaths from all causes that were considered. Studies were weighted using a random-effects model. The American Journal of Medicine 2016 129, 486-496.e2DOI: (10.1016/j.amjmed.2015.12.027) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Structurally normal hearts among sudden cardiac deaths in subjects aged ≤35 years. Forest plots display point estimates from individual studies, along with summary estimates and confidence intervals for the pooled proportion of sudden cardiac deaths with no known structural abnormality at post-mortem documentation (eg, structurally normal heart). The data column headed by “Total SNHs” represents the total number of subjects with sudden cardiac death with structurally normal hearts in each study. The column headed by “Total SCDs” indicates the total number of sudden cardiac deaths from all causes. Studies were weighted using a random-effects model. The American Journal of Medicine 2016 129, 486-496.e2DOI: (10.1016/j.amjmed.2015.12.027) Copyright © 2016 Elsevier Inc. Terms and Conditions

Appendix Figure Flow diagram of search strategy. This Figure displays the process of study screening and final study selection after review of 1559 unique citations. A total of 34 original research studies with appropriate study design and sufficient data reporting were included. The American Journal of Medicine 2016 129, 486-496.e2DOI: (10.1016/j.amjmed.2015.12.027) Copyright © 2016 Elsevier Inc. Terms and Conditions