Osteoarthritis year 2010 in review: pharmacological therapies

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Osteoarthritis year 2010 in review: pharmacological therapies F. Berenbaum Osteoarthritis and Cartilage Volume 19, Issue 4, Pages 361-365 (April 2011) DOI: 10.1016/j.joca.2011.01.019 Copyright © 2011 Terms and Conditions

Fig. 1 Cumulative proportion of patients with adjudicated clinically significant events throughout the GI tract. Proportion of patients with the primary endpoint was estimated on the basis of the cox-proportional model. [Reprinted from The Lancet, Vol 376, Chan FKL, Lanas A., Scheiman J., Berger MF, Nguyen H., Goldstein JL. Celecoxib vs omeprazole and diclofenac in patients with OA and RA (CONDOR): a randomised trial. pp. 173–179., Copyright 2011, with permission from Elsevier]. Osteoarthritis and Cartilage 2011 19, 361-365DOI: (10.1016/j.joca.2011.01.019) Copyright © 2011 Terms and Conditions

Fig. 2 Differences in pain intensity measured on VAS between experimental interventions and placebo over time. Shading represents area of clinical equivalence. Negative values indicate benefit of experimental interventions compared with placebo. (Reprinted from BMJ 341:doi:10.1136/bmj.c4675. Wandel S, Jüni P, Tendal B, Nüesch E, Villiger PM, Welton NJ, Reichenbach S, Trelle S. Effects of glucosamine, chondroitin, or placebo in patients with OA of hip or knee: network meta-analysis. Copyright 2011, with permission from BMJ). Osteoarthritis and Cartilage 2011 19, 361-365DOI: (10.1016/j.joca.2011.01.019) Copyright © 2011 Terms and Conditions

Fig. 3 Patients’ assessment of pain while walking. The patient’s assessment of knee pain while walking were obtained at baseline and at the indicated times with the use of a visual analogue scale that ranged from 0 to 100. In the case of knee pain, a decrease in the score indicates improvement (i.e., less pain). Changes are reported as least-squares means ± standard error (SE). P < 0.001 for the comparisons of all doses of tanezumab with placebo in the assessment of knee pain (Copyright 2011, with permission from the New England Journal of Medicine). Osteoarthritis and Cartilage 2011 19, 361-365DOI: (10.1016/j.joca.2011.01.019) Copyright © 2011 Terms and Conditions