Céline Jumeau et al. BTS 2016;j.jacbts

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Céline Jumeau et al. BTS 2016;j.jacbts.2016.05.002 DTIs Reduce Myocardial and Matrix Remodeling in Left Atria Rats with MI were treated with vehicle or 25 mg/kg/day dabigatran etexilate for 4 weeks or 6 mg/kg/day S35972 for either 8 or 4 weeks, with initiation of treatment 1 month after MI (shifted 4 weeks). (A) Masson trichrome or (B) picrosirius red staining of atrial sections. Representative images were from the same rat in each group (n = 5 to 7). Magnification was ×100 and ×600. Atrial (C and D) and ventricular (E) messenger ribonucleic acid (mRNA) of connective tissue growth factor (CTGF) and plasminogen activator inhibitor 1 (PAI-1) were measured by real-time polymerase chain reaction. n = 3 to 11; exact p values in blue are calculated versus sham rats and those in red versus vehicle-treated rats with MI. Abbreviations as in Figure 1. Céline Jumeau et al. BTS 2016;j.jacbts.2016.05.002 The Authors