Exploring Personalized Prophylaxis in Hemophilia A

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Presentation transcript:

Exploring Personalized Prophylaxis in Hemophilia A

Introduction

Personalizing Therapy

Concept of PK Personalization

PK Variability

Individual Variability

Population PK Studies

ISTH Recommendation on Population PK Studies

WAPPS-Hemo Database

Case 1

Performing the PopPK Study

Case 1: Results From WAPPS-Hemo

Dose Simulations

Case 1: Outcomes

Patient-Provider Communication

Case 2

Case 2: Results From WAPPS-Hemo

Dosing Options

Case 2: Outcomes

Treatment Logs

PK Samples

Examples of Patients Who Should Undergo PK Studies

Concluding Remarks

Abbreviations