Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging

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Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging Xiao Tian, Andrei Seluanov, Vera Gorbunova Cell Metabolism Volume 25, Issue 5, Pages 991-992 (May 2017) DOI: 10.1016/j.cmet.2017.04.022 Copyright © 2017 Terms and Conditions

Figure 1 Potential Strategies to Delay Aging Caused by Accumulation of DNA Damage DNA damage leads to aging and functional decline by generating mutations, inducing cellular senescence, and causing metabolic dysregulation due to persistent DNA damage signaling. These deleterious effects of DNA damage can be targeted either individually through elimination of senescent cells or inhibition of DNA-PK, or, more comprehensively, by developing strategies to improve DNA repair. Cell Metabolism 2017 25, 991-992DOI: (10.1016/j.cmet.2017.04.022) Copyright © 2017 Terms and Conditions