Jacek M. Karski, MDa, Sally J

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Presentation transcript:

Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid Jacek M. Karski, MDa, Sally J. Teasdale, MDa, Peter Norman, MDa, Jo Carroll, RN, Karl VanKessel, BSc, Peter Wong, BSc, M.F.X. Glynn, MDb† The Journal of Thoracic and Cardiovascular Surgery Volume 110, Issue 3, Pages 835-842 (September 1995) DOI: 10.1016/S0022-5223(95)70118-4 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Blood loss, autotransfusion, and RBC transfusion compared between patients with and without excessive bleeding. Patients with excessive bleeding lost significantly more blood and received significantly more autotransfusion and RBC transfusion than patients without excessive bleeding. Bleeder, Patients with more than 750 ml blood loss in first 6 postoperative hours; nonbleeder, patients with less than 750 ml blood loss in first 6 postoperative hours (20 patients randomly selected from control). 1Patients who had excessive bleeding lost 184% more blood during initial 6 hours (p = 0.0001). 2Patients who had excessive bleeding required increased volume of autotransfusion (250%, p = 0.0001). 3Patients who had excessive bleeding received increased volume of RBC transfusion (93%, p = NS). The Journal of Thoracic and Cardiovascular Surgery 1995 110, 835-842DOI: (10.1016/S0022-5223(95)70118-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Blood loss during periods from 0 to 6 hours, 6 to24 hours, and 0 to 24 hours after operation. 1Blood loss from 0 to 6 hours is reduced by 50% in TA-10 group and 53% in TA-20 group compared with that in control group (p = 0.0001). There was no difference in blood loss between TA-10 and TA-20 groups. 2Blood loss from 6 to 24 hours was reduced by 21% in TA-20 group compared with that in control group (p =0.03). Blood loss in TA-10 group was not statistically significant when compared with that in control group. 3Total blood loss during first 24 hours after operation was reduced by 35% in TA-10 group and 37% in TA-20 group compared with that in control group (p = 0.0001). There was no difference in blood loss between TA-10 and TA-20 groups. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 835-842DOI: (10.1016/S0022-5223(95)70118-4) Copyright © 1995 Mosby, Inc. Terms and Conditions