Kai Ihnken, MD, Kiyozo Morita, MD, Gerald D Buckberg, MD

Slides:

Advertisements

Similar presentations

Relative Changes in Cerebral Blood Flow During Cardiac Operations Using Xenon-133 Clearance Versus Transcranial Doppler Sonography Uday H Trivedi, FRCS,

Advertisements

Repeat Sternotomy: No Longer a Risk Factor in Mitral Valve Surgical Procedures Mehrdad Ghoreishi, MD, Murtaza Dawood, MD, Gerald Hobbs, PhD, Chetan Pasrija,

Yuji Hiramatsu, MDa, Nicolas Gikakis, BSEa, Harry L

The Myocardial Protective Effects of a Moderate-Potassium Blood Cardioplegia in Pediatric Cardiac Surgery: A Randomized Controlled Trial Yang Liu, MD,

Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial.

Studies of hypoxemic/reoxygenation injury: Without aortic clamping:

Relative Changes in Cerebral Blood Flow During Cardiac Operations Using Xenon-133 Clearance Versus Transcranial Doppler Sonography Uday H Trivedi, FRCS,

Studies of hypoxemic/reoxygenation injury: Without aortic clamping

Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach Michael T. Kronon,

Effect of l-arginine or nitroglycerine during deep hypothermic circulatory arrest in neonatal lambs Shinichi Hatsuoka, MD, Takahiko Sakamoto, MD, Ulrich.

Studies of hypoxemic/reoxygenation injury: With aortic clamping

Cardiac performance after deep hypothermic circulatory arrest in chronically cyanotic neonatal lambs Mitsugi Nagashima, MDa, Georg Nollert, MDa, Ulrich.

The role of cardioplegia induction temperature and amino acid enrichment in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD,

James L Zellner, MD, Scott B Kribbs, BS, B

Bashir M Matata, PhD, Andrzej W Sosnowski, MD, Manuel Galiñanes

Effect of perfusion flow rate on tissue oxygenation in newborn piglets during cardiopulmonary bypass Gregory Schears, MD, Steven E Schultz, MD, Jennifer.

Superiority of magnesium cardioplegia in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson,

Resuscitation After Prolonged Cardiac Arrest: Role of Cardiopulmonary Bypass and Systemic Hyperkalemia Oliver J. Liakopoulos, MD, Bradley S. Allen, MD,

Cardiac troponin I release after open heart surgery: a marker of myocardial protection? Emmanuelle Vermes, MD, Martine Mesguich, MD, Rémi Houel, MD, Céline.

Effects of Depletion of Leukocytes and Platelets on Cardiac Dysfunction After Cardiopulmonary Bypass Yukio Chiba, Kouichi Morioka, Ryusuke Muraoka, Akio.

Total Liquid Ventilation Reduces Lung Injury in Piglets After Cardiopulmonary Bypass Lijun Jiang, MD, Qiang Wang, MD, Yinglong Liu, MD, Ming Du, MD, Xiangdong.

Decreased exhaled nitric oxide may be a marker of cardiopulmonary bypass–induced injury Maurice Beghetti, MD, Philip E Silkoff, Marlova Caramori, MD,

Magnesium-supplemented warm blood cardioplegia in patients undergoing coronary artery revascularization Mark Yeatman, Massimo Caputo, MD, Pradeep Narayan,

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Basel Ramlawi, MD, MMSc, Hasan Otu, PhD, Shigetoshi Mieno, MD, Munir.

Detrimental Effects of Cardiopulmonary Bypass in Cyanotic Infants: Preventing the Reoxygenation Injury Bradley S. Allen, MD, Shaikh Rahman, MS, Michel.

An Analysis of Oxygen Consumption and Oxygen Delivery in Euthermic Infants After Cardiopulmonary Bypass With Modified Ultrafiltration Jia Li, MD, PhD,

Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts Jeffrey M Pearl, MD, David P Nelson, MD, PhD, Steven M Schwartz,

Studies of hypoxemic/reoxygenation injury with aortic clamping

Gerald D. Buckberg, MD, Kai Ihnken, MD, Kiyozo Morita, MD

Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery John L Francis, PhD, George J Palmer, MD, Rebecca Moroose,

Cardiac Output Augmentation During Hypoxemia Improves Cerebral Metabolism After Hypothermic Cardiopulmonary Bypass Jess M. Schultz, MD, Tara Karamlou,

Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction

Hannu J Penttilä, MD, Martti V

Coronary surgery without cardiotomy suction and autotransfusion reduces the postoperative systemic inflammatory response Martin Westerberg, MD, Anders.

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange Manuel Castellá, MDa, Gerald D. Buckberg, MDa,

Myocardial protection in normal and hypoxically stressed neonatal hearts: The superiority of hypocalcemic versus normocalcemic blood cardioplegia Kirk.

Nitecapone as an additive to crystalloid cardioplegia in patients who had coronary artery bypass grafting Antti E Vento, MD, Juha Aittomäki, MD, Kalervo.

Free radical reaction products and antioxidant capacity in arterial plasma during coronary artery bypass grafting Hannu J. Toivonen, MD, PhDa, Markku.

Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass

Effects of perfusion mode on regional and global organ blood flow in a neonatal piglet model Akif Ündar, PhD, Takafumi Masai, MD, Shuang-Qiang Yang,

Repeat Sternotomy: No Longer a Risk Factor in Mitral Valve Surgical Procedures Mehrdad Ghoreishi, MD, Murtaza Dawood, MD, Gerald Hobbs, PhD, Chetan Pasrija,

Effect of hemoglobin concentration on oxyhemoglobin dissociation during hypothermic blood cardioplegic arrest William L. Holman, MD, Walter V.A. Vicente,

The effects of normoxic versus hyperoxic cardiopulmonary bypass on oxidative stress and inflammatory response in cyanotic pediatric patients undergoing.

Ischemic postconditioning promotes left ventricular functional recovery after cardioplegic arrest in an in vivo piglet model of global ischemia reperfusion.

Anticoagulation with bivalirudin during cardiopulmonary bypass in cardiac surgery Julio C Vasquez, MD, Anna Vichiendilokkul, PharmD, Syed Mahmood, MD,

Platelet and Neutrophil Activation During Cardiac Surgical Procedures: Impact of Cardiopulmonary Bypass David S Morse, David Adams, Barbarajean Magnani

Kai Ihnken, MD The Journal of Thoracic and Cardiovascular Surgery

Clinical evaluation of leukocyte-depleted blood cardioplegia for pediatric open heart operation Yoshitaka Hayashi, MD, Yoshiki Sawa, MD, Motonobu Nishimura,

Ara K. Pridjian, MD, Edward L. Bove, MD, Flavian M. Lupinetti, MD

Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart Zhi-Li Cao, MD, Yukio Okazaki, MD, Kozo Naito, MD, Tetsuya Ueno,

Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest Ru Lin,

Time course of proinflammatory and anti-inflammatory responses after cardiac operation: monocyte HLA-DR expression Y.John Gu, MD, PhD, Willem van Oeveren,

Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass Jeffrey M.

Effect of cardiopulmonary bypass on pulmonary gas exchange: a prospective randomized study Craig M Cox, Raimondo Ascione, MD, Alan M Cohen, Ian M Davies,

Protection of the human heart with ischemic preconditioning during cardiac surgery: role of cardiopulmonary bypass Sudip Ghosh, MD, Manuel Galiñanes,

Postbypass effects of delayed rewarming on cerebral blood flow velocities in infants after total circulatory arrest Rosendo A. Rodriguez, MD, PhDa (by.

Intermittent Warm Blood Cardioplegia Preserves Myocardial β-Adrenergic Receptor Function Massimo Chello, Pasquale Mastroroberto, Vincenzo De Amicis,

Effect of Nitric Oxide Gas on Platelets During Open Heart Operations

Giant Cardiac Fibroma The Annals of Thoracic Surgery

Fraser D. Rubens, MD, MS, Gilbert Lavalee, Marc A

Michael T. Kronon, MD, Bradley S

L-arginine, prostaglandin, and white cell filtration equally improve myocardial protection in stressed neonatal hearts Michael T. Kronon, MD, Bradley.

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Leukocyte-depleted terminal blood cardioplegia provides superior myocardial protective effects in association with myocardium-derived nitric oxide and.

Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass Song Wan, MDa, Jean-Marie DeSmet, MDa, Luc Barvais,

Roderick W Landymore, MD, Alexander J Bayes, MD, J

Dumbor L. Ngaage, MD, FRCS (C-Th), Michael E. Cowen, FRCS

Karl A. Bocchieri, BS, CCP, S. Jacob Scheinerman, MD, L

Safety of low hematocrits during cardiopulmonary bypass

Presentation transcript:

Delayed cardioplegic reoxygenation reduces reoxygenation injury in cyanotic immature hearts Kai Ihnken, MD, Kiyozo Morita, MD, Gerald D Buckberg, MD The Annals of Thoracic Surgery Volume 66, Issue 1, Pages 177-182 (July 1998) DOI: 10.1016/S0003-4975(98)00320-8

Fig 1 Postbypass myocardial contractility expressed as percentage of recovery of end-systolic elastance. (Control = animals undergoing cardiopulmonary bypass without hypoxemia or cardioplegic arrest; No Hypoxemia = piglets undergoing cardioplegic arrest on cardiopulmonary bypass without hypoxemia; NoRx = hypoxemic animals undergoing reoxygenation on cardiopulmonary bypass including cardioplegic arrest; Rx = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus Control and No Hypoxemia; ∗∗ = p < 0.05 versus NoRx. The Annals of Thoracic Surgery 1998 66, 177-182DOI: (10.1016/S0003-4975(98)00320-8)

Fig 2 Antioxidant reserve capacity. Vulnerability of hypoxemic and reoxygenated myocardium to subsequent oxidant stress is determined by exposing cardiac homogenates to 0 to 4 mmol/L t-butylhydroperoxide. (MDA = malondialdehyde; Control [closed triangles] = animals undergoing cardiopulmonary bypass without hypoxemia or cardioplegic arrest; No hypoxemia [open circles] = piglets undergoing cardioplegic arrest on cardiopulmonary bypass without hypoxemia; NoRx [closed circles] = hypoxemic animals undergoing reoxygenation on cardiopulmonary bypass including cardioplegic arrest; Rx [open triangles] = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus all other groups.) The Annals of Thoracic Surgery 1998 66, 177-182DOI: (10.1016/S0003-4975(98)00320-8)

Fig 3 Myocardial conjugated diene (CD) production (as a marker of lipid peroxidation) during cardioplegic induction. (No hypoxemia = piglets undergoing cardioplegic arrest on CPB without hypoxemia; NoRx = hypoxemic animals undergoing reoxygenation on CPB including cardioplegic arrest; Rx = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus NoRx.) The Annals of Thoracic Surgery 1998 66, 177-182DOI: (10.1016/S0003-4975(98)00320-8)

Fig 4 Plasma conjugated diene levels from coronary sinus blood. (BCP = blood cardioplegic arrest; Control [closed squares] = animals undergoing cardiopulmonary bypass [CPB] without hypoxemia or cardioplegic arrest; No hypoxemia [open triangles] = piglets undergoing cardioplegic arrest on CPB without hypoxemia; NoRx [closed circles] = hypoxemic animals undergoing reoxygenation on CPB including cardioplegic arrest; Rx [open circles] = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus all other groups.) The Annals of Thoracic Surgery 1998 66, 177-182DOI: (10.1016/S0003-4975(98)00320-8)

Fig 5 Myocardial oxygen consumption (O2) during cardioplegic induction. (No hypoxemia [open circles] = piglets undergoing cardioplegic arrest on cardiopulmonary bypass without hypoxemia; NoRx [closed circles] = hypoxemic animals undergoing reoxygenation on cardiopulmonary bypass including cardioplegic arrest; Rx [open triangles] = hypoxemic piglets treated with delayed reoxygenation; ∗ = p < 0.05 versus No hypoxemia; ∗∗ = p < 0.05 versus NoRx.) The Annals of Thoracic Surgery 1998 66, 177-182DOI: (10.1016/S0003-4975(98)00320-8)