This Month in Gastroenterology Jan Tack, John M. Carethers  Gastroenterology  Volume 134, Issue 7, Pages 1815-1818 (June 2008) DOI: 10.1053/j.gastro.2008.05.002 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Life table analysis (Kaplan-Meier) of the patient outcomes. (A) Analysis in both groups (Con, continuation; Dis, discontinuation) of the need for early rescue infliximab or stopping infliximab therapy (primary endpoint). (B) Analysis in both groups of the need to stop further infliximab therapy. Gastroenterology 2008 134, 1815-1818DOI: (10.1053/j.gastro.2008.05.002) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Comparison of diurnal change in girth (distension) between hypersensitive, normosensitive and hyposensitive patients in IBS patients overall (IBS-all) IBS patients with constipation (IBS-C), and IBS patients with diarrhea (IBS-D). Data are expressed as mean values and 95% confidence intervals. #P < .001 compared with hypersensitive; *P < .01 compared with hypersensitive; +P < .1 compared with normosensitive. Gastroenterology 2008 134, 1815-1818DOI: (10.1053/j.gastro.2008.05.002) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 TRPV4 ligands selectively modulate mechanosensory function. Splanchnic colonic mesenteric afferents show increased responses to static application of a 2-g von Frey hair in the presence of the TRPV4 agonist 5,6-EET (i), which is lost in the TRPV4 null mutant (ii). Conversely, the nonselective TRP blocker ruthenium red concentration-dependently inhibits mechanosensory responses (iii), and effect that is lost in the TRPV4-null mutants (iv). Gastroenterology 2008 134, 1815-1818DOI: (10.1053/j.gastro.2008.05.002) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 MSCs rescue lethal fulminant hepatic failure. Survival curves of NOD-SCID mice intravenously transplanted with 1.4 × 107 to 4.2 × 107/kg of MSCs at 24 hours after administration of 0.28 ml/kg CCl4 by gavage completely rescued survival. Gastroenterology 2008 134, 1815-1818DOI: (10.1053/j.gastro.2008.05.002) Copyright © 2008 AGA Institute Terms and Conditions