Fentanyl HCl iontophoretic transdermal system (ITS): clinical application of iontophoretic technology in the management of acute postoperative pain I.

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Fentanyl HCl iontophoretic transdermal system (ITS): clinical application of iontophoretic technology in the management of acute postoperative pain I. Power British Journal of Anaesthesia Volume 98, Issue 1, Pages 4-11 (January 2007) DOI: 10.1093/bja/ael314 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 1 Schematic diagram of iontophoretic drug delivery (Ag/AgCl electrode system). Iontophoretic devices typically utilize anodal transport, in which the ionizable drug (D+) and its counter-ion (A−) are contained within the anodal compartment, to administer therapeutics transdermally. A low-intensity electric current (e) repels ionized drug molecules (D+) from the anodal drug reservoir, driving them across the epidermis and into the subdermal tissue, where they are absorbed into the systemic circulation. Simultaneously, chloride ions (Cl−) are repelled from the cathode hydrogel reservoir. To maintain electroneutrality, oppositely charged ions, primarily Cl− and Na+, move into the anode and cathode reservoirs, respectively. Source: Presented with permission from Kalia YN, et al. Adv Drug Deliv Rev 2004; 56: 619–58.29 British Journal of Anaesthesia 2007 98, 4-11DOI: (10.1093/bja/ael314) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 2 The fentanyl HCl iontophoretic transdermal system (fentanyl ITS). LED, light-emitting diode. Source: Provided by Janssen Pharmaceutica NV, Beerse, Belgium. British Journal of Anaesthesia 2007 98, 4-11DOI: (10.1093/bja/ael314) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 3 Area under the serum concentration–time curve (AUC) values normalized to the AUC value from hours 23 to 24 of treatment (AUC23–24). Patients were treated with the fentanyl ITS according to the following medication schedule: 2 consecutive doses per hour for 23.33 h (48 total doses). Source: Adapted with permission from Sathyan G, et al. Clin Pharmacokinet 2005; 44 (Suppl. 1):17–24.48 British Journal of Anaesthesia 2007 98, 4-11DOI: (10.1093/bja/ael314) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions