Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Interpretation Criteria for Assessment of Antibiotic Treatment Response in Pyogenic.

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Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Interpretation Criteria for Assessment of Antibiotic Treatment Response in Pyogenic Spine Infection Silvia A. Riccio, MD, Angel K.M. Chu, MD, Harvey R. Rabin, MD, Reinhard Kloiber, MD Canadian Association of Radiologists Journal Volume 66, Issue 2, Pages 145-152 (May 2015) DOI: 10.1016/j.carj.2014.08.004 Copyright © 2015 Canadian Association of Radiologists Terms and Conditions

Figure 1 Coronal computed tomography (CT), fluorodeoxyglucose positron emission tomography (18F-FDG PET), and fused PET/CT images of the lumbar spine in an 88-year-old man (A-C) and 51-year-old woman (D-F) with no history of infection showing focal and linear increased 18F-FDG activity, respectively, confined to margins of degenerated vertebral endplates. This figure is available in colour online at http://carjonline.org/. Canadian Association of Radiologists Journal 2015 66, 145-152DOI: (10.1016/j.carj.2014.08.004) Copyright © 2015 Canadian Association of Radiologists Terms and Conditions

Figure 2 Comparison of maximum standardized uptake values (SUVmax) before and after treatment in both good and poor responders with proven and suspected infection as compared to noninfected patients. Reference refers to the 4 of 500 oncology patients without evidence of infection who showed increased activity at degenerated discs. Canadian Association of Radiologists Journal 2015 66, 145-152DOI: (10.1016/j.carj.2014.08.004) Copyright © 2015 Canadian Association of Radiologists Terms and Conditions

Figure 3 Coronal computed tomography (CT), fluorodeoxyglucose positron emission tomography (18F-FDG PET), and fused PET/CT images of the thoracic spine in a 68-year-old woman (#26) with active PSI at T5-6 and good response to intravenous antibiotic treatment. Before treatment, 18F-FDG activity is seen within the soft tissues with SUVmax 9.9 (A-C); 35 days later, residual 18F-FDG activity is confined to the destroyed disc space with SUVmax 7.4 (D-F). This figure is available in colour online at http://carjonline.org/. Canadian Association of Radiologists Journal 2015 66, 145-152DOI: (10.1016/j.carj.2014.08.004) Copyright © 2015 Canadian Association of Radiologists Terms and Conditions

Figure 4 Coronal CT, 18F-FDG PET and fused PET/CT images of the thoracic spine in a 67 year old man (#17) with active PSI at T9-10 and poor response to treatment. Before treatment maximum standardized uptake values (SUVmax) is 6.8 (A-C). 60 days later, persistent 18F-FDG activity is seen in the soft tissues and deep within bone, with SUVmax 8.0 (D-F). This figure is available in colour online at http://carjonline.org/. Canadian Association of Radiologists Journal 2015 66, 145-152DOI: (10.1016/j.carj.2014.08.004) Copyright © 2015 Canadian Association of Radiologists Terms and Conditions