Multiple Sclerosis Rare disease < 200,000 cases per year Autoimmune disease affecting myelin Familial history increases risk (HLA) Caucasian highest risk Females ~twice as likely affected No cure Symptomatic treatments (e.g. corticosteroids) Modify progression (Capaxone)

<5% <1% 10% 85%

Team Workshop 1:Use the ExAC database to explore exome variants in the HLA-DRB1 gene. List variants that could affect peptide binding (http://exac.broadinstitute.org/)

Team Workshop 2: Use the Clinical Trials Website to explore current RRMS drugs in clinical trials. Choose a trial with results and list the drug, the sponsor and the cohort number ( https://clinicaltrials.gov/ct2/home )

Team Workshop 3: Choose 2 of the drugs from Workshop 2 and determine the mechanism of action (MOA) using drugbank https://www.drugbank.ca/

Remember Before 12 PM of the next class day: go to b.socrative.com/student/login and complete the quiz