Aberrant wound architecture and proliferation in Rev3l-deficient skin.

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Presentation transcript:

Aberrant wound architecture and proliferation in Rev3l-deficient skin. Aberrant wound architecture and proliferation in Rev3l-deficient skin. (A) Keratin-10 staining of skin sections from wounds from BK5.Cre; Rev3l+/lox and BK5.Cre; Rev3l−/lox mice 10 d after wounding. Distance bar: 100 μm. (B) Quantification of keratin-10–negative epidermal cells (basal cells), average size of epidermal keratinocytes, and epidermal cell density (n = 4 mice of each genotype) 10 d after wounding. (C) GFP fluorescence of the keratinocyte outgrowth from a skin explant 6 d after plating. (D) GFP (keratinocyte) and Hoechst 33342 dye (nuclei) from a skin explant 5 d after plating in culture. The total area of cell outgrowth and the number of nuclei in that area of outgrowth are shown. (E) Quantification of the total outgrowth area from skin explants at 5–8 d after plating and cell density at 5 d after plating (n = 3 mice per genotype). Data points are mean ± SEM; *P < 0.05, **P < 0.01. Sabine S Lange et al. LSA 2018;1:e201800048 © 2018 Lange et al.