Multifaceted Contributions of Epidermal Langerhans Cells to Cutaneous Carcinogenesis  Björn E. Clausen, Stephan Grabbe  Journal of Investigative Dermatology  Volume 135, Issue 5, Pages 1218-1220 (May 2015) DOI: 10.1038/jid.2014.520 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Regulation of skin carcinogenesis by Langerhans cells and dermal APC. Tumor cells are painted in red, normal keratinocytes in blue, and mutated keratinocytes are depicted by their red nuclei. PAHs are illustrated by purple dots. CYP1B1, cytochrome P450 enzyme 1B1; DC, (dermal) dendritic cell; DMBADE, DMBA-t-3,4-diol-1,2-epoxide; LC, Langerhans cell; PAH, polyaromatic hydrocarbons; Teff, effector T cell; Treg, regulatory T cell. Journal of Investigative Dermatology 2015 135, 1218-1220DOI: (10.1038/jid.2014.520) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions