Volume 4, Issue 1, Pages (January 2018)

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Volume 4, Issue 1, Pages 67-71 (January 2018) Paraneoplastic pemphigus mimicking toxic epidermal necrolysis: An underdiagnosed entity? R. Matthew McLarney, MD, Rodrigo H. Valdes-Rodriguez, MD, Gabriel Isaza-Gonzalez, MD, Jason H. Miller, MD, Sylvia Hsu, MD, Kiran Motaparthi, MD JAAD Case Reports Volume 4, Issue 1, Pages 67-71 (January 2018) DOI: 10.1016/j.jdcr.2017.11.002 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Erythroderma with widespread and confluent epidermal detachment resembles toxic epidermal necrolysis. B, Severe mucositis including erosive cheilitis with hemorrhagic crust was also present. JAAD Case Reports 2018 4, 67-71DOI: (10.1016/j.jdcr.2017.11.002) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A, Suprabasilar acantholysis with tombstoning of the basilar keratinocytes (single arrow) and keratinocyte necrosis (double arrow) are present together. B, Vacuolar interface dermatitis (single arrow) underlies keratinocyte apoptosis. C, Overlying the intraepidermal blister, there is parakeratosis and dymaturation, with dyskeratotic cells in the stratum corneum (single arrow), indicative of chronicity. D, Weak focal cell surface (single arrow) and junctional (double arrow) reactivity. (A-C, Hematoxylin-eosin stain; original magnification: A, ×100; B and C, ×200.) (D, Anti-IgG direct immunofluorescence; original magnification: ×100.) JAAD Case Reports 2018 4, 67-71DOI: (10.1016/j.jdcr.2017.11.002) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions