Safia Costes, Peter C. Butler  Cell Metabolism 

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Insulin-Degrading Enzyme Inhibition, a Novel Therapy for Type 2 Diabetes?  Safia Costes, Peter C. Butler  Cell Metabolism  Volume 20, Issue 2, Pages 201-203 (August 2014) DOI: 10.1016/j.cmet.2014.07.016 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Roles of IDE in Glucose Homeostasis, Gastric Emptying, and Regulation of Amyloidogenic Protein Levels Based on Studies with Pharmacological IDE Inhibition or Ide Knockout Mice IDE deficit increases the abundance and signaling of the pancreatic hormones insulin, amylin, and glucagon. Increased insulin improves glucose tolerance, and increased amylin levels slow postprandial gastric emptying. On the right is shown that IDE deficit increases levels of amylin, α-synuclein, and Aβ monomers which, via subsequent formation of toxic oligomers, impair secretory function and survival of pancreatic β cells and neurons. Cell Metabolism 2014 20, 201-203DOI: (10.1016/j.cmet.2014.07.016) Copyright © 2014 Elsevier Inc. Terms and Conditions