Why this pesky enzyme is widening your waistline!

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Presentation transcript:

Why this pesky enzyme is widening your waistline! 11bHSD1: Why this pesky enzyme is widening your waistline! By: Carrie Jones, ND, MPH

Disclosures: Medical Director of Precision Analytical, Inc. Copyright 2017: Carrie Jones, ND, MPH

Copyright 2017: Carrie Jones, ND, MPH

What is the (simplified) stress response? Copyright 2017: Carrie Jones, ND, MPH

11-Beta hydroxysteroid dehydrogenase Copyright 2017: Carrie Jones, ND, MPH

Where is 11bHSD1 most prevalent? Copyright 2017: Carrie Jones, ND, MPH

Where is 11bHSD2 most prevalent? Copyright 2017: Carrie Jones, ND, MPH

It’s a balance, right? Copyright 2017: Carrie Jones, ND, MPH

This is a fat cell Copyright 2017: Carrie Jones, ND, MPH

In the fat cell… Cortisone Cortisol 11bHSD1 Even when cortisol everywhere else in the body is ‘in balance’ it can get amplified in fat cells  Copyright 2017: Carrie Jones, ND, MPH

The Result? Copyright 2017: Carrie Jones, ND, MPH

How do I test 11bHSD activity? Research says you have to look at urinary cortisol and cortisone metabolites THF (cortisol) to THE (cortisone) ratio Copyright 2017: Carrie Jones, ND, MPH

Testing: ↑Total cortisol production/metabolism Prefers cortisol systemically due to 11bHSD1 Copyright 2017: Carrie Jones, ND, MPH

Increases 11bHSD1 Genetics Inflammation Insulin Obesity itself  Thyroid dysfunction Licorice supplementation Glucocorticoid use Copyright 2017: Carrie Jones, ND, MPH

Treatment goals! Copyright 2017: Carrie Jones, ND, MPH

Consider: Address the inflammation, thyroid, insulin, hormones, licorice supplementation or medication Flavonoids Magnolia EGCG Zizyphus vulgaris Scutellaria baicalensis Ocinum sanctum Healthy bile acid Copyright 2017: Carrie Jones, ND, MPH

Thank you for listening! Copyright 2017: Carrie Jones, ND, MPH

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