When Should We Suspect Hereditary Colorectal Cancer Syndrome? Xavier Llor  Clinical Gastroenterology and Hepatology  Volume 10, Issue 4, Pages 363-367 (April 2012) DOI: 10.1016/j.cgh.2011.12.022 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Proposed schema for LS diagnosis. The proposed strategy incorporates the performance of MLH1 methylation and/or BRAF (V600E) point mutation analysis if that is available. IHC would start with the most common proteins responsible for LS, MSH2 and MLH1. If those were normally expressed, we would proceed to testing MSH6 and PMS2. Clinical Gastroenterology and Hepatology 2012 10, 363-367DOI: (10.1016/j.cgh.2011.12.022) Copyright © 2012 AGA Institute Terms and Conditions