William K. Funkhouser, Ira M. Lubin, Federico A. Monzon, Barbara A

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Presentation transcript:

Relevance, Pathogenesis, and Testing Algorithm for Mismatch Repair–Defective Colorectal Carcinomas William K. Funkhouser, Ira M. Lubin, Federico A. Monzon, Barbara A. Zehnbauer, James P. Evans, Shuji Ogino, Jan A. Nowak The Journal of Molecular Diagnostics Volume 14, Issue 2, Pages 91-103 (March 2012) DOI: 10.1016/j.jmoldx.2011.11.001 Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 1 The relationship of the CIMP-H, BRAF 1799T>A (p.V600E), and MSI-H variables in new colorectal carcinomas. Each variable is seen in approximately 15% of new CRC cases, and there is significant overlap among the variables, detailed in the subjacent table. All cases with MLH1 PHM are MSI-H, but only 75% to 80% of cases with MSI-H show MLH1 PHM. The Journal of Molecular Diagnostics 2012 14, 91-103DOI: (10.1016/j.jmoldx.2011.11.001) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 2 The proposed testing strategy and the possible test outcomes, downstream additional testing, subgroup assignment, prognosis, and prediction of therapeutic response. The Journal of Molecular Diagnostics 2012 14, 91-103DOI: (10.1016/j.jmoldx.2011.11.001) Copyright © 2012 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions