No Need for Constant Help: Human IgG2 Antibodies Have an Autonomous Agonistic Activity for Immunotherapy of Cancer Anja Lux, Falk Nimmerjahn Cancer.

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No Need for Constant Help: Human IgG2 Antibodies Have an Autonomous Agonistic Activity for Immunotherapy of Cancer Anja Lux, Falk Nimmerjahn Cancer Cell Volume 27, Issue 1, Pages 10-11 (January 2015) DOI: 10.1016/j.ccell.2014.12.010 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Pathways Responsible for the Activity of Mouse and Human Agonistic Antibody Activity In Vivo In mice, IgG1 antibodies have sufficiently high activity to mediate agonistic effects via binding to the inhibitory FcγRIIB. In humans, the IgG2 subclass has an intrinsic capacity to trigger agonistic antibody-dependent effects and does not require higher order crosslinking. See text for further details. Cancer Cell 2015 27, 10-11DOI: (10.1016/j.ccell.2014.12.010) Copyright © 2015 Elsevier Inc. Terms and Conditions