Major response to vemurafenib in patient with severe cutaneous Langerhans cell histiocytosis harboring BRAF V600E mutation Julie Charles, MD, PhD, Jean-Claude.

Slides:

Advertisements

Similar presentations

Topically applied ascorbic acid solution for the treatment of basal cell carcinoma (BCC) Péter Holló, MD, PhD, Hajnalka Jókai, MD, PhD, Judit Hársing,

Advertisements

Grover disease with a contagious twist

Steven Q. Wang, MD, Leonard H. Goldberg, MD, FRCP

Calcific elastosis in the setting of weight gain

Cutaneous polyarteritis nodosa presenting as a solitary blue toe

Cutaneous vasculitis in two patients taking an herbal supplement containing black cohosh Adam Ingraffea, BA, Kevin Donohue, MD, Caroline Wilkel, MD,

Volume 2, Issue 6, Pages (November 2016)

Accuracy of biopsy sampling for subtyping basal cell carcinoma

Volume 2, Issue 2, Pages (March 2016)

Diffuse hyperpigmented plaques as cutaneous manifestation of multicentric Castleman disease and treatment with thalidomide: Report of three cases Xiaoqing.

Aggressive cutaneous infection with Mycobacterium marinum in two patients receiving anti–tumor necrosis factor-alfa agents Julie Caron, MD, Carine Michot,

Lymphomatoid papulosis in a young adult of African descent

Expression of PD-L1 in mastocytosis

Varicella-zoster virus vaccination–induced granulomatous dermatitis

Palisaded neutrophilic and granulomatous dermatitis associated with limited systemic sclerosis Basil M. Hantash, MD, PhD, David Chiang, Sabine Kohler,

Photo-induced Stevens-Johnson syndrome

Primary thyroid marginal zone B-cell lymphoma in a patient with psoriatic arthritis treated with etanercept Hyunju Jin, MD, Hyun-Ho Cho, MD, Won-Jeong.

Cholangiocarcinoma with skin metastases

Rapid deterioration in a patient with primary aggressive cutaneous epidermotropic CD8+ cytotoxic T-cell (‘Berti’) lymphoma after administration of adalimumab

Volume 2, Issue 5, Pages (September 2016)

Clinicopathologic features and T-cell receptor gene rearrangement findings of mycosis fungoides palmaris et plantaris Sang-Tae Kim, MD, Young-Seung Jeon,

Atypical lymphocytic reaction with epidermotropism and lymphocytic vasculopathic reaction (lymphocytic vasculitis) after treatment with imiquimod Jesús.

Melanoma in skin affected with keratoderma palmoplantaris hereditaria (Mal de Meleda): Treatment with excision and grafting Leonardo Sartore, MD, Matteo.

Mid-dermal elastolysis as a manifestation of immune reconstitution inflammatory syndrome in an HIV-infected patient Carlo Cota, MD, Alessandra Latini,

Development of a reticular rash in a febrile woman: An unusual cutaneous presentation of angioimmunoblastic T-cell lymphoma Michelle S. Min, MSci, Jonathan.

Volume 1, Issue 4, Pages (July 2015)

Rachel L. Kyllo, BS, Mary Kendall Parker, MD, Ilana Rosman, MD, Amy C

A definitive case of metastatic folliculotropic melanoma

Sanghoon Lee, MD, Sang Gun Park, MD, Min-Geol Lee, MD, PhD

Volume 1, Issue 2, Pages (March 2015)

Digital metastasis of tongue squamous cell carcinoma

Justin J. Leitenberger, BS, Cindy N. Berthelot, MD, Kristel D

Myiasis in a giant squamous cell carcinoma

A nonsteroidal alternative to impetiginized eczema in the emergency room Benjamin Stoff, MD, Jamie MacKelfresh, MD, Levi Fried, Cynthia Cohen, MD, Jack.

Scleroderma-like changes in cutaneous eruption of rhabdomyolysis

Solitary mastocytoma in an adult with an unusual clinical presentation

Pyoderma gangrenosum in a patient with cutaneous T-cell lymphoma

Bullous rheumatoid neutrophilic dermatosis

Lupus erythematosus–like skin eruption after vemurafenib therapy

Romidepsin-induced neutrophilic urticaria

Cutaneous involvement in multiple myeloma mimicking acral-lentiginous melanoma Antonio Martorell, MD, Fernando Millan-Parrilla, MD, Enrique Gimeno-Carpio,

Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sézary syndrome Alexander Kreuter, MD, Peter Altmeyer, MD

Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases Alan S. Boyd, MD, Bashar Shakhtour,

Lip edema Journal of the American Academy of Dermatology

Localized nephrogenic fibrosing dermopathy: Aberrant dermal repairing?

Volume 3, Issue 5, Pages (September 2017)

Solomon Shockman, MD, Lauren Krug, MD, Nektarios Lountzis, MD

Intradermal injection of autologous platelet-rich plasma for the treatment of vulvar lichen sclerosus Andrew T. Goldstein, MD, Michelle King, MSc, Charles.

Infliximab in the treatment of a child with cutaneous granulomas associated with ataxia telangiectasia Angana Mitra, MBChB, Jimmy Gooi, MBChB, Jonathan.

Volume 4, Issue 8, Pages (September 2018)

Acute generalized exanthematous pustulosis induced by mifepristone

Volume 1, Issue 5, Pages (September 2015)

Volume 1, Issue 5, Pages (September 2015)

Grace A. Hile, BS, Lori Lowe, MD, J. Michelle Kahlenberg, MD, PhD

Hovik J. Ashchyan, BA, Katherine K. Brown, MD JAAD Case Reports

Volume 4, Issue 1, Pages (January 2018)

Emilie Doré Badje, MD, Trilok Tejasvi, MD, Alexandra Hristov, MD

Pigmented mammary Paget disease positive for melanocytic markers

Multisystemic Langerhans cell histiocytosis in an adult

Jose Fernández-Vozmediano, PhD, Jose Armario-Hita, MD

Treatment of cutaneous pseudolymphoma with interferon alfa-2b

Marked and restricted cutaneous pigmentation induced by selective intra-arterial cisplatin infusion Teruki Yanagi, MD, Masashi Akiyama, MD, PhD, Satoru.

Vesiculopustules in adult-onset Still's disease

Acanthosis nigricans in a patient with sarcoma of unknown origin

Grace A. Hile, BS, Lori Lowe, MD, J. Michelle Kahlenberg, MD, PhD

Topically applied ascorbic acid solution for the treatment of basal cell carcinoma (BCC) Péter Holló, MD, PhD, Hajnalka Jókai, MD, PhD, Judit Hársing,

Orit Kaidar-Person, MD, Ayelet Eran, MD, Gil Bar-Sela, MD

Volume 5, Issue 7, Pages (July 2019)

Cutaneous polyarteritis nodosa presenting as a solitary blue toe

Atypical pemphigus involving the esophagus with IgG antibodies to desmoglein 3 and IgA antibodies to desmoglein 1 Shigeki Inui, MD, PhD, Masayuki Amagai,

Presentation transcript:

Major response to vemurafenib in patient with severe cutaneous Langerhans cell histiocytosis harboring BRAF V600E mutation Julie Charles, MD, PhD, Jean-Claude Beani, MD, Giacomo Fiandrino, MD, Benoit Busser, PharmD, PhD Journal of the American Academy of Dermatology Volume 71, Issue 3, Pages e97-e99 (September 2014) DOI: 10.1016/j.jaad.2014.03.038 Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Langerhans cell histiocytosis and vemurafenib response. Inframammary folds (upper images) and left groin area (lower images) before and after a 6-months period of vemurafenib treatment. Journal of the American Academy of Dermatology 2014 71, e97-e99DOI: (10.1016/j.jaad.2014.03.038) Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histologic and immunohistologic pictures of Langerhans cell histiocytosis. A, Histologically, tumor cells were medium-sized, with grooved or indented nuclei and abundant eosinophilic cytoplasms. Moderate cellular pleomorphism was also a feature. Mitoses were not exceptional, with absence of overtly atypical forms. B, Low-power view of the biopsy specimen before treatment. C, Tumor cells were uniformly stained by the CD1a antibody, which also highlighted epidermotropic tumor cells. D, After 3 weeks of vemurafenib treatment, the dermal infiltrate had entirely disappeared, being replaced by mixed inflammatory cells. E, After treatment, immunostaining for CD1a was restricted to skin-resident Langerhans cells. (A, B, and D, Hematoxylin-eosin stain; original magnifications: A, ×40; B, ×2.5; D, ×2.5. C and E, SABC; original magnifications: C, ×10; E, ×5.) Journal of the American Academy of Dermatology 2014 71, e97-e99DOI: (10.1016/j.jaad.2014.03.038) Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions