Soluble C5b-9 as a Biomarker for Complement Activation in Atypical Hemolytic Uremic Syndrome Fengxiao Bu, MS, Nicole C. Meyer, BS, Yuzhou Zhang, PhD,

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Soluble C5b-9 as a Biomarker for Complement Activation in Atypical Hemolytic Uremic Syndrome Fengxiao Bu, MS, Nicole C. Meyer, BS, Yuzhou Zhang, PhD, Nicolo Ghiringhelli Borsa, BS, Christie Thomas, MD, Carla Nester, MD, Richard J.H. Smith, MD American Journal of Kidney Diseases Volume 65, Issue 6, Pages 968-969 (June 2015) DOI: 10.1053/j.ajkd.2015.02.326 Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Readouts of sC5b-9 in patients with aHUS with acute and inactive disease are inconsistent among laboratories (outliers defined as >1.5×IQR). Data from: (A) this publication (Molecular Otolaryngology and Renal Research Laboratories, MORL), Table 2 from Noris et al2 (samples without sC5b-9 values excluded), supplemental Fig 1c from Cataland et al4 (excluding 2 outliers), and (B) Table 3 from Volokhina et al.3 Dashed rectangles demarcate group-specific normal ranges. (C) P values of intergroup comparisons using Wilcoxon-Mann-Whitney test. American Journal of Kidney Diseases 2015 65, 968-969DOI: (10.1053/j.ajkd.2015.02.326) Copyright © 2015 National Kidney Foundation, Inc. Terms and Conditions