Therapeutic targeting of the tumor microenvironment Johanna A. Joyce  Cancer Cell  Volume 7, Issue 6, Pages 513-520 (June 2005) DOI: 10.1016/j.ccr.2005.05.024 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Therapeutic strategies that have been designed or suggested to target different cells in the tumor microenvironment These strategies include targeting the tumor cells themselves, with traditional therapies such as chemotherapy and radiotherapy (which will also kill normal cells) and targeted vaccines, or molecular approaches to inhibit oncogenes such as Ras, EGFR, and Her2. Among the targets to inhibit in normal cells are members of the VEGF/VEGFR family (vascular or lymphatic endothelial cells), PDGF/PDGFR family (pericytes and potentially fibroblasts and lymphatics), matrix-degrading enzymes (made by inflammatory cells in large part, with BM/ECM components as substrates), and inhibitors of chronic inflammation. Cancer Cell 2005 7, 513-520DOI: (10.1016/j.ccr.2005.05.024) Copyright © 2005 Elsevier Inc. Terms and Conditions