Old mice drug-treated for 6 months

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Old mice drug-treated for 6 months Accumulation of p16Ink4a-positive cells Heart Eyes Kidney Nervous system Adipose tissue Lipodystrophy Reduced activity Cataracts Glomerulosclerosis Kidney dysfunction Cardiomyocyte hypertrophy Loss of cardiac stress tolerance Cancer Ageing Reduced healthspan Old mice drug-treated for 6 months Specific ablation of p16Ink4a-positive cells Kidney Improved renal function Nervous system Increased activity Adipose tissue Delayed ageing Increased healthspan Preserved fat content Eyes Reduction in cataracts Heart Reduced tumor latency Recover of cardiac stress tolerance