Biomarkers in Cancer Immunotherapy

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Biomarkers in Cancer Immunotherapy Ton N. Schumacher, Can Kesmir, Marit M. van Buuren Cancer Cell Volume 27, Issue 1, Pages 12-14 (January 2015) DOI: 10.1016/j.ccell.2014.12.004 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Neo-Antigen Signatures and Other Biomarkers within the Cancer-Immunity Cycle (A) The percentage of nonameric peptides containing one of the tetrapeptide motifs within either documented neo-epitopes (left, n = 13) or nonameric peptides derived from the human proteome predicted to bind with an affinity of ≤ 500nM to HLA-A∗01:01, A∗02:01, A∗03:01, B∗07:02, or B∗08:01 (right, n = 2,327,696). The blue chart piece represents the percentage of epitopes containing one of the motifs. (B) Opportunities for biomarker discovery (blue) in the cancer-immunity cycle. Reprinted and adapted from Chen and Mellman (2013) with permission from Elsevier. Cancer Cell 2015 27, 12-14DOI: (10.1016/j.ccell.2014.12.004) Copyright © 2015 Elsevier Inc. Terms and Conditions