Lecture 7: Biological Network Crosstalk Y. Z

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Presentation transcript:

Lecture 7: Biological Network Crosstalk Y. Z Lecture 7: Biological Network Crosstalk Y.Z. Chen Department of Pharmacy National University of Singapore Tel: 65-6616-6877; Email: phacyz@nus.edu.sg ; Web: http://bidd.nus.edu.sg Content Literature described network crosstalk Cross-talks in diseases and biological regulation Mechanism of regulation of cross-talking pathways New methods for network crosstalk discovery Generation of maps of large-scale networks

Integrated circuit of the cell

Pathways Involved in Cancer: Multiple regulation

Pathways Involved in Cancer: Energy Metabolism and Cell Survival

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk ?

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Literature Described Network Crosstalk

Cross-Talks in Diseases

Cross-Talks in Diseases

Cross-Talks in Diseases

Cross-Talks in Diseases

Cross-Talks in Diseases

Cross-Talks in Diseases

Cross-Talks in Diseases

Cross-Talks in Diseases

Cross-Talks in Diseases

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Cross-Talks in Biological Regulation

Mechanism of Regulation of Cross-talking Pathways

Mechanism of Regulation of Cross-talking Pathways

Mechanism of Regulation of Cross-talking Pathways

Mechanism of Regulation of Cross-talking Pathways

Mechanism of Regulation of Cross-talking Pathways

Mechanism of Regulation of Cross-talking Pathways

New Network Crosstalk Discovery Methods I: Expression Profiling

New Network Crosstalk Discovery Methods I: Expression Profiling

New Network Crosstalk Discovery Methods I: Expression Profiling Finding promoters of commonly expressed genes

New Network Crosstalk Discovery Methods I: Expression Profiling Identifying target genes and network effects regulated by identified promoters

New Network Crosstalk Discovery Methods II: Modeling

Generation of Maps of Large-Scale Networks

Generation of Maps of Large-Scale Networks

Generation of Maps of Large-Scale Networks

Generation of Maps of Large-Scale Networks

Generation of Maps of Large-Scale Networks

Generation of Maps of Large-Scale Networks

Generation of Maps of Large-Scale Networks

Generation of Maps of Large-Scale Networks

Generation of Maps of Large-Scale Networks