Effect of Irradiation on Incidence of Post-Transplant Lymphoproliferative Disorder after Hematopoietic Cell Transplantation in Miniature Swine Abraham.

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Effect of Irradiation on Incidence of Post-Transplant Lymphoproliferative Disorder after Hematopoietic Cell Transplantation in Miniature Swine Abraham J. Matar, Aarti R. Patil, Ahmad Al-Musa, Isabel Hanekamp, David H. Sachs, Christene A. Huang, Raimon Duran-Struuck Biology of Blood and Marrow Transplantation Volume 21, Issue 10, Pages 1732-1738 (October 2015) DOI: 10.1016/j.bbmt.2015.07.017 Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 PTLD incidence. Incidence of PTLD in animals that received a conditioning regimen with SCF/IL3 + no irradiation (■), SCF/IL3 + TBI (♦), SCF/IL3 + TI (▲), or G-CSF + TBI (▼). *P < .05. Biology of Blood and Marrow Transplantation 2015 21, 1732-1738DOI: (10.1016/j.bbmt.2015.07.017) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 T cell depletion. Level of T cell depletion in animals on day 0 after receiving a conditioning regimen with CD3 immunotoxin and either no irradiation (n = 16), 1000 cGy TI (n = 28), or 100 cGy TBI (n = 37). Absolute CD3+ T cells from naive swine are provided for comparison. Biology of Blood and Marrow Transplantation 2015 21, 1732-1738DOI: (10.1016/j.bbmt.2015.07.017) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Comparison between absolute T cell numbers in animals with and without PTLD after receiving different conditioning regimens. (A) Post-HCT day 0 absolute T cell counts in animals treated with TI. (B) Absolute T cell counts on post-HCT day 0 after conditioning with TBI. (C) Absolute T cell counts 2 weeks post-HCT in animals that received SCF/IL3 with TBI. Biology of Blood and Marrow Transplantation 2015 21, 1732-1738DOI: (10.1016/j.bbmt.2015.07.017) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 LDH. (A) Representative serum LDH levels (U/L) at the time of PTLD diagnosis (6034 U/L) compared with serum LDH levels in animals without PTLD (1392 U/L) (P = .0002). (B) Representative data of serum LDH levels over time from pre-HCT to clinical lymphadenopathy in an animal (18861) developing PTLD. (C) LDH levels detected by ELISA in 5 previously established porcine PTLD tumor cell lines (14736, 13271, 15446, 17016L [lymph node origin], 17016P [peritoneal origin], 17018) compared with LDH levels from normal peripheral blood leukocytes. Statistical significance with a P < .0001 between groups marked with different number of asterisks (*). Groups that have the same number (*) are not statistically significant between each other. Biology of Blood and Marrow Transplantation 2015 21, 1732-1738DOI: (10.1016/j.bbmt.2015.07.017) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions