Mouse models for the study of HCV infection and virus–host interactions  Heidi Barth, Eric Robinet, T. Jake Liang, Thomas F. Baumert  Journal of Hepatology  Volume 49, Issue 1, Pages 134-142 (July 2008) DOI: 10.1016/j.jhep.2008.03.012 Copyright © 2008 Terms and Conditions

Fig. 1 Chimeric transgenic mice repopulated with human hepatocytes for the study of HCV infection. Hemizygous Alb-uPA mice were crossed to homozygosity with homozygous SCID/bg mice. The resulting Alb-uPA/SCID mice can be transplanted with human hepatocytes and support HCV infection from human infected-serum or recombinant cell culture-derived HCV (HCVcc). This model has been successfully used to study virus–host interactions in infected hepatocytes as well as the evaluation of antiviral strategies including antiviral drugs and monoclonal antibodies. The evaluation of cell therapy products may represent another application of this model in the future. Journal of Hepatology 2008 49, 134-142DOI: (10.1016/j.jhep.2008.03.012) Copyright © 2008 Terms and Conditions