David J. Nikolic-Paterson, Shuang Wang, Hui Yao Lan

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Presentation transcript:

Macrophages promote renal fibrosis through direct and indirect mechanisms David J. Nikolic-Paterson, Shuang Wang, Hui Yao Lan Kidney International Supplements Volume 4, Issue 1, Pages 34-38 (November 2014) DOI: 10.1038/kisup.2014.7 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Evidence for macrophage-myofibropblast transition (MMT) in human fibrotic kidney disease. Confocal microscopy reveals that severe renal fibrosis in a patient with IgA nephropathy (IgAN) is associated with numerous MMT cells identified by co-expression of alpha smooth muscle action (α-SMA) (red) and CD68 (green). Such MMT cells are absent in a case of minimal change disease (MCD). A, arteriole; arrows identify α-SMA+ CD68+ double-positive MMT cells. Magnification: × 400. Kidney International Supplements 2014 4, 34-38DOI: (10.1038/kisup.2014.7) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Evidence for bone marrow-derived macrophage-myofibropblast transition (MMT) in the mouse model of unilateral ureteric obstruction (UUO). A day-7 UUO study was performed in chimeric mice with a green fluorescence protein (GFP) + bone marrow compartment. Confocal microscopy showed that the severe renal fibrosis on day-7 UUO is associated with numerous α-SMA + F4/80 + GFP + MMT cells in the obstructed kidney but not in the sham-operated kidney. An MMT cell is illustrated in the inserted picture of each panel. Magnification: × 400. Kidney International Supplements 2014 4, 34-38DOI: (10.1038/kisup.2014.7) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 3 Two-color flow cytometry detects macrophage-myofibropblast transition (MMT) cells in wild-type mice in the unilateral ureteric obstruction (UUO) model. Two-color immunofluorescence staining show that the majority of alpha smooth muscle action (α-SMA) + myofibroblasts co-express the macrophage F4/80 antigen in a single-cell suspension of the obstructed kidney prepared by enzyme digestion. However, this is not the case in the sham-operated kidney. Kidney International Supplements 2014 4, 34-38DOI: (10.1038/kisup.2014.7) Copyright © 2014 International Society of Nephrology Terms and Conditions