One-stage focal cartilage defect treatment with bone marrow mononuclear cells and chondrocytes leads to better macroscopic cartilage regeneration compared.

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One-stage focal cartilage defect treatment with bone marrow mononuclear cells and chondrocytes leads to better macroscopic cartilage regeneration compared to microfracture in goats J.E.J. Bekkers, L.B. Creemers, A.I. Tsuchida, M.H.P. van Rijen, R.J.H. Custers, W.J.A. Dhert, D.B.F. Saris Osteoarthritis and Cartilage Volume 21, Issue 7, Pages 950-956 (July 2013) DOI: 10.1016/j.joca.2013.03.015 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Macroscopic scores 6 months after treatment. Macroscopic scores show no differences between the treatments at 6 months follow-up for the medial femur (MFC) and tibia (MTP) surfaces, lateral femur (LFC) and tibia (LTP) surfaces and the articulating defect surface. At the treated defect site the chondrocyteMNF treatment showed a statistically significant (P = 0.015) higher macroscopic ICRS score compared to the microfracture-treated defects. Scores are presented as boxplots. Osteoarthritis and Cartilage 2013 21, 950-956DOI: (10.1016/j.joca.2013.03.015) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Representative examples of macroscopic repair after 6 months follow-up. Macroscopic examples of defect fill at 6 months follow-up for both treatments. Microfracture treatment showed incomplete macroscopic defect fill while the chondrocyteMNF treatment showed complete macroscopic fill. Osteoarthritis and Cartilage 2013 21, 950-956DOI: (10.1016/j.joca.2013.03.015) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Microscopic scores 6 months after treatment. Microscopic scores for the articular cartilage surrounding and directly articulating with the treated defect and the lateral femur (LFC) and tibia (LTP) surfaces for both the chondrocyteMNF (MNF) and microfracture (MF) treatment. No statistically significant differences were observed in microscopic score between the two treatments for the mentioned scores. However, a trend toward statistical significance (P = 0.067) was observed in microscopic score between chondrocyteMNF and microfracture treatment at the treated defect. Scores are presented as boxplots. Osteoarthritis and Cartilage 2013 21, 950-956DOI: (10.1016/j.joca.2013.03.015) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Best, mean and worst result of microscopic repair after 6 months follow-up. Cross-sectional slices perpendicular to the center of the treated defect at 6 months follow-up for the best, mean and worst result of both treatments showing incomplete defect fill for the microfracture treatment while nearly complete defect fill following chondrocyteMNF was observed in some cases. Osteoarthritis and Cartilage 2013 21, 950-956DOI: (10.1016/j.joca.2013.03.015) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions