Hallmarks of Cancer.

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Presentation transcript:

Hallmarks of Cancer

Cells within a tissue are VERY organized and closely monitored and regulated Normal Cells

Normal Cells Most have limitations on division Stem Cells Most normal cells differentiate Contact inhibition Undergo apoptosis

Cancer Cells Sustain proliferative signaling “gas pedal stuck on” Evade growth suppressors “brakes don’t work”

Cancer Cells Resist cell death won't die when body would kill defective cell Enable replicative immortality infinite generations of descendants

Cancer Cells Induce angiogenesis recruits blood vessels Activating invasion and metastasis** migrating and spreading to other parts of the body

Updated Hallmarks (still in review) Deregulated metabolism Evade the immune system Unstable DNA Inflammation