Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study Caryn S Ross-Innes,

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Presentation transcript:

Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study Caryn S Ross-Innes, PhD, Hamza Chettouh, PhD, Achilleas Achilleos, PhD, Nuria Galeano-Dalmau, MSc, Irene Debiram-Beecham, MSc, Shona MacRae, PhD, Petros Fessas, BA, Elaine Walker, BSc, Sibu Varghese, PhD, Theodore Evan, MBBChir, Pierre S Lao- Sirieix, Maria O'Donovan, FRCPath, Shalini Malhotra, FRCPath, Prof Marco Novelli, FRCPath, Babett Disep, FRCPath, Phillip V Kaye, FRCPath, Prof Laurence B Lovat, FRCPath, Rehan Haidry, FRCPath, Prof Michael Griffin, FRCS, Prof Krish Ragunath, FRCP, Prof Pradeep Bhandari, FRCPath, Adam Haycock, MRCP, Danielle Morris, MRCP, Prof Stephen Attwood, FRCS, Anjan Dhar, FRCP, Prof Colin Rees, FRCP, Prof Matt D Rutter, FRCP, Richard Ostler, MSc, Benoit Aigret, MSc, Peter D Sasieni, PhD, Prof Rebecca C Fitzgerald, MD The Lancet Gastroenterology & Hepatology Volume 2, Issue 1, Pages 23-31 (January 2017) DOI: 10.1016/S2468-1253(16)30118-2 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Flow chart. NDBO=non-dysplastic Barrett's oesophagus. HGD=high-grade dysplasia. IMC=intramucosal adenocarcinoma. The Lancet Gastroenterology & Hepatology 2017 2, 23-31DOI: (10.1016/S2468-1253(16)30118-2) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 2 Examples of significant and non-significant staining for the three protein biomarkers as well as an example of glandular atypia as seen on a Cytosponge sample The Lancet Gastroenterology & Hepatology 2017 2, 23-31DOI: (10.1016/S2468-1253(16)30118-2) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 3 Risk classification results for discovery cohort patients The Lancet Gastroenterology & Hepatology 2017 2, 23-31DOI: (10.1016/S2468-1253(16)30118-2) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 4 Intervention follow-up of patients with low-grade dysplasia assigned to high-risk, moderate-risk, and low-risk groups by the Cytosponge risk score The Lancet Gastroenterology & Hepatology 2017 2, 23-31DOI: (10.1016/S2468-1253(16)30118-2) Copyright © 2017 Elsevier Ltd Terms and Conditions