COMBACTE – The Pillars https://www.combacte.com/ CLIN-Net: a high-quality clinical research network in all European countries; to develop GCP training program and offer certification LAB-Net: a high-quality laboratory network in all European countries; to assess existing laboratory methods and quality, develop specimen and strain repository STAT-Net: a high-quality network of statistical experts; to develop novel trial design strategies, improve of clinical trial delivery, conduct of advanced biostatistical and PK/PD modelling studies EPI-Net: a high quality network of epidemiologic surveillance experts and stakeholders in Europe; to map current systems, define methodological challenges, and develop research strategy for epidemiological studies; to pursue consensus for best-practices and support R&D for new, effective antibiotics 24/12/2018

EPI-Net: A call to action* Established in 2015, the objectives of the network include Optimise surveillance of Antimicrobial Resistance (AMR) and Healthcare Associated Infections (HAI) Develop a consensus programme and homogenous approach on current and future epidemiologic surveillance strategies in Europe Inform Public Health Action Guide Antimicrobial Development Create an EU network of exellence center for Infectious Diseases clinical trial 24/12/2018 *Ref: Tacconelli E et al. Surveillance for control of antimicrobial resistance. http://dx.doi.org/10.1016/S1473-3099(17)30485-1

EPI-Net: Activities Data collection 24/12/2018 Infographic kindly provided by COMBACTE

methodological gaps and limitations EPI-Net: Activities Data analysis and dissemination https://epinet-net.eu Surveillance experts Evidence base Communication of methodological gaps and limitations Academic journals Scientific meetings Surveillance guidance document 24/12/2018

EPI-Net: Activities EPI-Net excellence centres EPI-Net central database Hospitals or Universities not part of the COMBACTE consortium Epidemiology data on antibiotic-resistant bacteria and infections provided by participating centers Feedback to centers, including intervention plans, provided by EPI-Net 24/12/2018

EPI-Net publications  2018   Tacconelli E, Sifakis F, Harbarth S, Schrijver R, van Mourik M, Voss A, Sharland M, Babu Rajendran N, Rodríguez-Baño J, on behalf of the EPI-Net COMBACTE-MAGNET Group. Surveillance for control of antimicrobial resistance. Lancet Infectious Diseases. March 2018. http://dx.doi.org/10.1016/S1473-3099(17)30485-1    2017 Schrijver R, Stijntjes M, Rodríguez-Baño J, Tacconelli E, Rajendran NB, Voss A. A review of antimicrobial resistance surveillance programmes in livestock and meat thereof in Europe with a focus on antimicrobial resistance patterns in humans. Clin Microbiol Infect. September 2017. https://doi.org/10.1016/j.cmi.2017.09.013 Núñez-Núñez M, Navarro MD, Palomo V, Rajendran NB, Del Toro MD, Voss A, Sharland M, Sifakis F, Tacconelli E, Rodríguez-Baño J; EPI-Net, Combacte-Magnet and EUCIC Group for SUSPIRE. The methodology of surveillance for antimicrobial resistance and healthcare-associated infections in Europe (SUSPIRE): a systematic review of publicly available information. Clin Microbiol Infect. July 2017. https://doi.org/10.1016/j.cmi.2017.07.014 Núñez-Núñez M, Navarro MD, Gkolia P, Babu Rajendran N, Del Toro MD, Voss A, Sharland M, Sifakis F, Tacconelli E, Rodríguez-Baño J; and Members of the EPI-NET group on behalf of COMBACTE-MAGNET Consortium. Surveillance Systems from Public Health Institutions and Scientific Societies for Antimicrobial Resistance and Healthcare-Associated Infections in Europe (SUSPIRE): protocol for a systematic review. BMJ Open. March 2017. https://doi.org/10.1136/bmjopen-2016-014538 Babu Rajendran N, Gladstone BP, Rodríguez-Baño J, Sifakis F, Voss A, Carmeli Y, Burkert FR, Gkolia P, Tacconelli E. EpideMiology and control measures of outBreaks due to Antibiotic-Resistant orGanisms in EurOpe (EMBARGO): a systematic review protocol. BMJ Open. January 2017. https://doi.org/10.1136/bmjopen-2016-013634 24/12/2018 For latest EPI-Net publications, refer to epi-net.eu

The Network Academic leads Partner Centers EFPIA leads Evelina Tacconeli, UNIVR Nisar Malek, EKUT Jesús Rodríguez-Baño (co-leader), SAS Andreas Voss (co-leader), RNMC/CWH Partner Centers University of Verona (UNIVR) University Hospital of Tübingen (EKUT) University Medical Centre Utrecht (UMCU) Servicio Andaluz de Salud (SAS) University Medical Center Freiburg (UKF) Radboud University Nijmegen Medical Centre (RUNMC) Canisius-Wilhelmina Hospital (CWH) VetEffecT Université de Genève Paediatric European Network for the Treatment of AIDS and Infectious Diseases Astrazeneca/Medimmune (AZ/MI) Aicuris Basilea Sanofi GlaxoSmithKline EFPIA leads Frangiscos Sifakis, AZ/MI Cuong Vong, AiCuris Core research team Monica Compri, UNIVR Liliana Galia, UNIVR Diletta Pezzani, UNIVR Fulvia Mazzaferri, UNIVR Nithya Babu Rajendran, EKUT Beryl Primrose Gladstone, EKUT Virginia Paloma, SAS Blanca Anaya, SAS Zaira Palacios, SAS Nico Mutters, UKF Contact info@epi-net.eu 24/12/2018