Chronic lymphocytic leukemia and cryoglobulinemic glomerulonephritis

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Chronic lymphocytic leukemia and cryoglobulinemic glomerulonephritis S.H. Nasr, R.W. Snyder, G. Bhagat, G.S. Markowitz Kidney International Volume 71, Issue 2, (January 2007) DOI: 10.1038/sj.ki.5001891 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Renal biopsy findings. (a) A glomerulus exhibits diffuse endocapillary proliferation with prominent infiltrating neutrophils and monocytes. (Hematoxylin and eosin; original magnification, ×400.) (b) In another glomerulus, the large subendothelial fuchsinophilic (red) deposits are prominently seen (arrows). (Trichrome; original magnification, ×400.) (c) Low-power view showing a dense interstitial aggregate of monomorphic B cells, representing renal parenchymal infiltration by chronic lymphocytic leukemia. (Original magnification, ×100.) (d) The same field seen in panel c shows diffuse positivity for CD20, a marker of B cells. The leukemic cells also showed dim CD5 expression (not shown). (Original magnification, ×100.) Kidney International 2007 71, DOI: (10.1038/sj.ki.5001891) Copyright © 2007 International Society of Nephrology Terms and Conditions