Chapter 12: Post-transcriptional Gene Control and Nuclear Transport

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Presentation transcript:

Chapter 12: Post-transcriptional Gene Control and Nuclear Transport ~ By Ying Ly (Jessica)

Sections: 12.1 Processing of Eukaryotic Pre-mRNA 12.2 Regulation of Pre-mRNA Processing 12.3 Macromolecular Transport Across the Nuclear Envelope 12.4 Cytoplasmic Mechanisms of Posttranscriptional Control 12.5 Processing of rRNA and tRNA

Overview from DNA to mRNA

5’capping 5’Cap is Added to Nascent RNAs Shortly After the initiation by RNA polymerase II Carboxyl Terminal Domain (CTD) Heteronucleur Ribonuclealus protein (hnRNP) RNA-Binding motifs

Conserved RNA-Binding Motifs

Cleavage and Polyadenylation of Pre-mRNAs Are Tightly Coupled

Splicing: Where it Occurs

Splicing: Transesterfications

Splicing: snRNA

Splicing: Spliceosomes

Splicing: Summing it Up

Presentation Summary

Works Cited Lodish, H., Berk, A., Matsudaira, P., Kaiser, C.A., Krieger, M., Scott, M.P., Zipursky, S.L., and Darnell, J. “Chapter 12 Post-transitional Gene Control and Nuclear Transport.” Molecular Cell Biology. 5th ed. New York: W.H. Freeman and Company, 2004. Section 12.1 pp. 493-504.