Front-Line Memory T Cells Think Outside the T-box… Mostly Christopher M. Snyder  Immunity  Volume 43, Issue 6, Pages 1030-1032 (December 2015) DOI: 10.1016/j.immuni.2015.11.020 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Depicting the Expression of T-bet and Eomes during the Differentiation of Memory T Cells For circulating and lymphoid-localized T cells, the progression from effector to memory T cells is coupled to an increase in the expression of Eomes and a downregulation of T-bet (top). In contrast, for tissue-localized Trm cells, Carbone and colleagues show that development of a self-sustaining memory population depends on TGF-β driving a loss of Eomes from the cells, as well as the downregulation of T-bet (bottom) (Mackay et al., 2015). Importantly, residual T-bet expression in Trm cells is required for expression of both the IL-15R, which is critical for Trm cell survival, and IFN-γ, which is important for Trm cell function. Immunity 2015 43, 1030-1032DOI: (10.1016/j.immuni.2015.11.020) Copyright © 2015 Elsevier Inc. Terms and Conditions