NMD: Nonsense-Mediated Defense Andreas Wachter, Lisa Hartmann  Cell Host & Microbe  Volume 16, Issue 3, Pages 273-275 (September 2014) DOI: 10.1016/j.chom.2014.08.015 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 NMD Contributes to Defense Responses upon Bacterial and Viral Infection (A) TNL receptor mRNAs are targeted by NMD under normal conditions (top). Bacterial infection leads to NMD suppression, resulting in TNL accumulation and an immune response (bottom). (B) PVX and SFV viral (+)RNAs are subject to degradation via NMD in plants and mammalian cells, respectively (top). In the course of virus infection NMD becomes inhibited, facilitating viral replication (bottom). Cell Host & Microbe 2014 16, 273-275DOI: (10.1016/j.chom.2014.08.015) Copyright © 2014 Elsevier Inc. Terms and Conditions