Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos Maria Pino-Yanes, PhD, Christopher R.

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Presentation transcript:

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos Maria Pino-Yanes, PhD, Christopher R. Gignoux, PhD, Joshua M. Galanter, MD, MAS, Albert M. Levin, PhD, Catarina D. Campbell, PhD, Celeste Eng, BS, Scott Huntsman, MS, Katherine K. Nishimura, MHP, Pierre-Antoine Gourraud, PhD, Kiana Mohajeri, BS, Brian J. O'Roak, PhD, Donglei Hu, PhD, Rasika A. Mathias, PhD, Elizabeth A. Nguyen, BS, Lindsey A. Roth, MA, Badri Padhukasahasram, PhD, Andres Moreno-Estrada, MD, PhD, Karla Sandoval, MS, PhD, Cheryl A. Winkler, PhD, Fred Lurmann, MS, Adam Davis, MA, Harold J. Farber, MD, MSPH, Kelley Meade, MD, Pedro C. Avila, MD, Denise Serebrisky, MD, Rocio Chapela, MD, Jean G. Ford, MD, Michael A. Lenoir, MD, Shannon M. Thyne, MD, Emerita Brigino-Buenaventura, MD, Luisa N. Borrell, DDS, PhD, William Rodriguez-Cintron, MD, Saunak Sen, PhD, Rajesh Kumar, MD, MSPH, Jose R. Rodriguez-Santana, MD, Carlos D. Bustamante, MA, PhD, Fernando D. Martinez, MD, Benjamin A. Raby, MD, MPH, Scott T. Weiss, MD, Dan L. Nicolae, PhD, Carole Ober, PhD, Deborah A. Meyers, PhD, Eugene R. Bleecker, MD, Steven J. Mack, PhD, Ryan D. Hernandez, PhD, Evan E. Eichler, PhD, Kathleen C. Barnes, PhD, L. Keoki Williams, MD, PhD, Dara G. Torgerson, PhD, Esteban G. Burchard, MD, MPH Journal of Allergy and Clinical Immunology Volume 135, Issue 6, Pages 1502-1510 (June 2015) DOI: 10.1016/j.jaci.2014.10.033 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Fine mapping of ZNF365 in the GALA II study. Included in the plot are −log10(P values) of association with total serum IgE levels by chromosome position. The most significant SNP is represented by a diamond, and the results for the remaining SNPs are color coded to show their linkage disequilibrium with this SNP based on pairwise r2 values from the Latino populations of the 1000 Genomes Project. SNPs above the dashed line are genome-wide significant (P ≤ 5 × 10−8). Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Box plot showing the distribution of IgE levels for each copy of a chromosome of Native American (A), European (B), and African (C) ancestry at 6p21.33. Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Fine mapping results of 6p21.32-p22.1 in the GALA II study, focusing on the region showing genome-wide significant allelic associations. Included in the plot are −log10(P values) of association with total serum IgE levels by chromosome position. The most significant SNP is represented by a diamond, and the results for the remaining SNPs are color coded to show their linkage disequilibrium with this SNP based on pairwise r2 values from the Latino populations of the 1000 Genomes Project. SNPs above the dashed line are genome-wide significant (P ≤ 5 × 10−8). Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E6 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E7 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E8 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E9 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E10 Journal of Allergy and Clinical Immunology 2015 135, 1502-1510DOI: (10.1016/j.jaci.2014.10.033) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions