Examining the Latest Evidence in PAH

Background

Important Advances in PAH

Initial Therapy Determines Follow-Up

Treatment Options in PAH

Growing Use of Combination Therapy

An Evolving Paradigm: From Sequential to Initial Up-front Combination Therapy

AMBITION Study

Clinical Trial Data vs Registry Data

Candidates for Monotherapy

Determinants of Initial Treatment for PAH

Follow-Up in PAH: Clinical Practice Consistent With Guideline Recommendations

Risk Stratification in PAH

French Registry: Survival Based on Number of Low-Risk Criteria Achieved at First Evaluation

Registry Data Confirm Need for Early Diagnosis and Treatment Intensification

French Registry: BNP Subset Analysis

Achieving Low-Risk Status in PAH

Additional Testing With RHC

Weighing Patient Risks and Current Options

GRIPHON: Study Design

Effect of Selexipag on Primary Composite Endpoint in GRIPHON

GRIPHON: Treatment Effect by WHO FC Group

TRITON: Triple Up-front Combination Therapy

Putting It All Together -- What Do We Know?

Faculty Approaches to PAH Treatment

Patient-Centered Approach to PAH

Conclusion

Abbreviations

Abbreviations (cont)

Abbreviations (cont)