Katrina J. Allen, MBBS, BMedSc, FRACP, PhD, Jennifer J

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Presentation transcript:

Vitamin D insufficiency is associated with challenge-proven food allergy in infants Katrina J. Allen, MBBS, BMedSc, FRACP, PhD, Jennifer J. Koplin, PhD, Anne-Louise Ponsonby, MBBS, PhD, Lyle C. Gurrin, PhD, Melissa Wake, MD, FRACP, Peter Vuillermin, MBBS, FRACP, PhD, Pamela Martin, PhD, Melanie Matheson, PhD, Adrian Lowe, PhD, Marnie Robinson, MBBS, FRACP, Dean Tey, MBBS, FRACP, Nicholas J. Osborne, PhD, Thanh Dang, BSc, Hern-Tze Tina Tan, BSc, Leone Thiele, BA, MNSc, Deborah Anderson, RN, Helen Czech, RN, Jeeva Sanjeevan, MBBS, Giovanni Zurzolo, BSc, Terence Dwyer, PhD, Mimi L.K. Tang, MBBS, FRACP, FRCPA, PhD, David Hill, MBBD, FRACP, Shyamali C. Dharmage, MBBS, MSc, MD, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 4, Pages 1109-1116.e6 (April 2013) DOI: 10.1016/j.jaci.2013.01.017 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Prevalence of vitamin D insufficiency (open bar, ≤50 nmol/L) and deficiency (solid bar, ≤25 nmol/L) among various food allergy phenotypes (A) and food allergy with and without eczema among infants with both parents born in Australia (B). Compared with infants with neither eczema nor food allergy, vitamin D insufficiency was significantly more common in infants with food allergy with or without eczema (P < .005 for both comparisons) but not in infants with eczema alone (P = .87). Vitamin D insufficiency was also significantly more common among infants with 2 or more food allergies compared with infants with 1 food allergy (P = .045). Journal of Allergy and Clinical Immunology 2013 131, 1109-1116.e6DOI: (10.1016/j.jaci.2013.01.017) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 HealthNuts study participation and classification of food allergy status. *Note that some infants fell into more than 1 of these categories. Of these infants, 44 had at least 1 negative challenge to a food to which they were sensitized; however, their full status was unknown as they did not undergo a challenge to all foods to which they were sensitized. A sensitivity analysis was undertaken with these infants classified as “sensitized and tolerant” to examine the effect on the observed association between vitamin D levels and food allergy. †Some infants allergic to more than 1 food. Journal of Allergy and Clinical Immunology 2013 131, 1109-1116.e6DOI: (10.1016/j.jaci.2013.01.017) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Distribution of vitamin D levels in HealthNuts serum samples by parents’ country of birth (n = 708). Journal of Allergy and Clinical Immunology 2013 131, 1109-1116.e6DOI: (10.1016/j.jaci.2013.01.017) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions