The Possible Interaction between Receptor Activator of Nuclear Factor Kappa-B Ligand Expressed by Extramammary Paget Cells and its Ligand on Dermal Macrophages

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The Possible Interaction between Receptor Activator of Nuclear Factor Kappa-B Ligand Expressed by Extramammary Paget Cells and its Ligand on Dermal Macrophages Yumi Kambayashi, Taku Fujimura, Sadanori Furudate, Masayuki Asano, Aya Kakizaki, Setsuya Aiba Journal of Investigative Dermatology Volume 135, Issue 10, Pages 2547-2550 (October 2015) DOI: 10.1038/jid.2015.199 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Extramammary Paget’s disease lesions, both noninvasive and invasive, express receptor of activator nuclear factor kappa-B ligand and matrix metalloprotease-7. Immunohistochemical staining for RANKL (a–c) and MMP-7 (d–f). Scale bar=100 μm. The expression of RANKL mRNA (g) and MMP-7 mRNA (h) in laser-captured epidermis of EMPD was analyzed by quantitative RT-PCR, using the ΔΔCt method. The mean±SEM of data from three cases of EMPD and non-lesional skin is presented. The production of sRANKL from EMPD tissue culture was measured using ELISA (i). *P<0.05 by Student’s t-test (g–i). RT-PCR, reverse transcriptase–PCR. Journal of Investigative Dermatology 2015 135, 2547-2550DOI: (10.1038/jid.2015.199) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 CD163+ CD206+ Arg1+ M2 macrophages express RANK in the lesional skin of extramammary Paget’s disease. Immunohistochemical staining of EMPD for RANK (a) and CD163 (b). Double immunofluorescence staining of EMPD for CD163 and RANK (c) (red: CD163, green: RANK, blue: DAPI, yellow: merge), for CD3 and RANK (d) (red: CD3, green: RANK, blue: DAPI, yellow: merge), for CD163 and CD206 (e) (red: CD163, green: CD206, blue: DAPI, yellow: merge), and for CD163 and Arg1 (f) (red: CD163, green: Arg1, blue: DAPI, yellow: merge). Scale bar=100 μm (a and b) and 40 μm (c–f). Arg1, arginase 1; RANKL, receptor of activator nuclear factor kappa-B ligand. Journal of Investigative Dermatology 2015 135, 2547-2550DOI: (10.1038/jid.2015.199) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions