Nat. Rev. Rheumatol. doi: /nrrheum

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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.80 Figure 3 Genes of the T helper cell differentiation pathway implicated in rheumatic diseases Figure 3 | Genes of the T helper cell differentiation pathway implicated in rheumatic diseases. Pathway analysis of disease-associated genes has demonstrated that the T helper cell differentiation pathway has a key role in the pathogenesis of rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PsA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS). Genes associated with at least one rheumatic disease are highlighted in pink, and labels next to these genes show with which disease(s) they are associated. Solid and dotted lines indicate direct or indirect relationships, respectively. Direct interactions (chemical modifications) require that two molecules make direct physical contact with each other, as opposed to indirect interactions that do not have this requirement. CD40L, CD40 ligand; CXCR5, C‑X‑C chemokine receptor type 5; FOXP3, forkhead box protein P3; GATA3, trans-acting T‑cell-specific transcription factor GATA3; ICOS, inducible T cell co-stimulator; ICOSL, inducible T cell co-stimulator ligand; IFNγR, IFNγ receptor; IL‑2R, IL‑2 receptor; IL‑4R, IL‑4 receptor; IL‑6R, IL‑6 receptor; IL‑10R, IL‑10 receptor; IL‑12R, IL‑12 receptor; IL‑21R, IL‑21 receptor; RORγt, nuclear receptor RORγt; SHP2, tyrosine-protein phosphatase non-receptor type 11; STAT, signal transducer and activator of transcription; T‑bet, T‑box transcription factor TBX21; TCR, T cell receptor; TFH cell, T follicular helper cell; TGFβR, TGFβ receptor; TH cell, T helper cell; TNFR, TNF receptor; Treg cell, regulatory T cell. Eyre, S. et al. (2017) The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.80