Bing-Yen Wang, MD, Hsiao-Huang Chang, MD, PhD, I

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Peginterferon α-2b and Acute Allograft Failure in a Heart Transplant Recipient Bing-Yen Wang, MD, Hsiao-Huang Chang, MD, PhD, I.-Ming Chen, MD, Chun-Che Shih, MD, PhD, An-Hang Yang, MD, PhD The Annals of Thoracic Surgery Volume 89, Issue 5, Pages 1645-1647 (May 2010) DOI: 10.1016/j.athoracsur.2009.09.084 Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) The endomyocardial biopsy shows unremarkable heart tissue. No morphologic features suggestive of acute rejection are seen (hematoxylin-eosin stain; original magnification ×100). (B) Gross examination shows a dilated ventricle and surgical sutures on the aorta. (C) Vacuolar degeneration of cardiomyocytes is scattered in the myocardium. These vacuoles were demonstrated to contain lipid in the subsequent electronic microscopic examination (hematoxylin-eosin stain; original magnification ×100). (D) Lipid droplets in cardiomyocytes are demonstrated by electronic microscopic examination. Note that endothelial cells are devoid of lipid accumulation. Image was taken with an electron microscopy technique, with ultra-thin sections stained with uranyl acetate and lead citrate without special immunochemistry stain. Magnification: 5 µm. (E) Cardiac allograft vasculopathy. Concentric intimal proliferation is seen in the coronary artery. The media is of normal thickness and shows little lipoprotein deposition (hematoxylin-eosin stain; original magnification ×100). The Annals of Thoracic Surgery 2010 89, 1645-1647DOI: (10.1016/j.athoracsur.2009.09.084) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions