CHIPping Away at Base Excision Repair

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Presentation transcript:

CHIPping Away at Base Excision Repair Robert W. Sobol Molecular Cell Volume 29, Issue 4, Pages 413-415 (February 2008) DOI: 10.1016/j.molcel.2008.02.004 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Base Excision Repair Complex Formation and Regulation by Posttranslational Modification Model depicting DNA damage-initiated recruitment of the scaffold protein XRCC1-Lig III and subsequent recruitment of Pol β for the formation of a productive BER complex. Proteins not in a repair complex are subject to CHIP-mediated ubiquitylation and degradation. Question marks underlie the impact of Pol β or XRCC1 PTMs that might alter BER complex formation and CHIP-mediated ubiquitylation as a potential mode for crosstalk to govern BER capacity. Molecular Cell 2008 29, 413-415DOI: (10.1016/j.molcel.2008.02.004) Copyright © 2008 Elsevier Inc. Terms and Conditions